产品说明
SpecificationsSPECIES:MouseSOURCESPECIES:HumanCellsSEQUENCE:Asp23-Pro119FUSIONTAG:C-FctagTESTEDAPPLICATIONS:APPLICATIONS:ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly.PropertiesPURITY:Greaterthan95%asdeterminedbyreducingSDS-PAGE.Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest.PREDICTEDMOLECULARWEIGHT:38.1kDPHYSICALSTATE:LyophilizedBUFFER:Lyophilizedfroma0.2umfilteredsolutionofPBS,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O.STORAGECONDITIONS:Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks.Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days.Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months.AdditionalInfoALTERNATENAMES:Serine/threonine-proteinkinasereceptorR3,SKR3,Activinreceptor-likekinase1,ALK-1,TGF-BsuperfamilyreceptortypeI,TSR-I,ACVRL1,activinAreceptortypeII-like1,activinAreceptorACCESSIONNO.:Q61288BackgroundActivinReceptor-LikeKinase1(ALK-1)isatypeIcell-surfacereceptorfortheTGF-betasuperfamilyofligands,whichmediatessignalingofBMP9(bonemorphogeneticprotein)andBMP10.ALK1signalingisnecessaryforangiogenesisduringembryogenesis,woundhealing,andtumorgrowth.ALK-1hasahighdegreeofsimilarityinserine-threoninekinasesuBDomains,aglycineandserinerichregionprecedingthekinase-domain,andaC-terminaltailwithotheractivinreceptor-likekinaseproteins.ALK-1ismainlyexpressedinendothelialcellsregulatingproliferationandmigrationinvitroandangiogenesisinvivo.MutationsinALK-1aswellasinendoglinareassociatedwithhereditaryhemorrhagictelangiectasia(HHT),suggestingALK-1playsacriticalroleforinthecontrolofbloodvesseldevelopmentorrepair.
ProSci
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Prosci/ABCG2 / BCRP Peptide/43-5...
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Prosci/ABCD4 Antibody/25-883/50 ...
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Prosci/ABHD13 Antibody/30-576/50...
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Prosci/ALK-1 Recombinant Protein...
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Prosci/ABCF3 Peptide/46-797P/0.1...