产品说明
SpecificationsSPECIES:MouseSOURCESPECIES:HumanCellsSEQUENCE:Val24-Leu187FUSIONTAG:C-FctagTESTEDAPPLICATIONS:APPLICATIONS:ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly.PropertiesPURITY:Greaterthan95%asdeterminedbyreducingSDS-PAGE.Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest.PREDICTEDMOLECULARWEIGHT:44.7kDPHYSICALSTATE:LiquidBUFFER:Suppliedasa0.2umfilteredsolutionof20mMPB,150mMNaCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O.STORAGECONDITIONS:Storeat-20˚C,stablefor6monthsafterreceipt.Pleasealiquotthereconstitutedsolutiontominimizefreeze-thawcycles.AdditionalInfoALTERNATENAMES:SecretedCD137antigen,Tumornecrosisfactorreceptorsuperfamilymember9,Tnfrsf9,TNFRSF9,CD137ACCESSIONNO.:P20334BackgroundTumornecrosisfactorreceptorsuperfamilymember9(TNFRSF9)isamemberofthetumornecrosisfactor(TNF)receptorfamily.Itcanbeinducedbylymphocyteactivation(ILA)andisexpressedbyactivatedTcells,buttoalargerextentonCD8thanonCD4Tcells.Inaddition,TNFRSF9expressionisfoundondendriticcells,folliculardendriticcells,naturalkillercells,granulocytesandcellsofbloodvesselwallsatsitesofinflammation.AsreceptorforTNFSF9/4-1BBL,itcanactivateTcellsandthecross-linkingofthisproteincanenhanceTcellproliferation,IL-2secretionsurvivalandcytolyticactivity.Further,itcanenhanceimmuneactivitytoeliminatetumorsinmice.
ProSci
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