Specifications SPECIES REACTIVITY:Human, Mouse TESTED APPLICATIONS:WB APPLICATIONS:Western Blot: 1:500~1:1000 PREDICTED MOLECULAR WEIGHT:100 kDa SPECIFICITY:This antibody detects endogenous level of α-catenin only when phosphorylated at serine 641. IMMUNOGEN:a-catenin (Phospho-Ser641) antibody was raised against a peptide sequence around phosphorylation site of serine 641 (D-D-S (p) -D-F) derived from Human α-catenin. HOST SPECIES:Rabbit Properties PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. PHYSICAL STATE:Liquid BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. CONCENTRATION:1 mg/mL STORAGE CONDITIONS:Store antibody at -20˚C for up to one year. CLONALITY:Polyclonal CONJUGATE:Unconjugated Additional Info ALTERNATE NAMES:CAP102, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, Cadherin-associated protein, Alpha E-catenin, NY-REN-13 antigen ACCESSION NO.:NP_001894.2 PROTEIN GI NO.:55770844 OFFICIAL SYMBOL:CTNNA1 GENE ID:1495 Background BACKGROUND:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation. REFERENCES: 1) Hwang, S. G. et al. (2005) J. Biol. Chem. 280, 12758-12765Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.