产品说明
Mannosereceptortargetingbymannosylatedliposomeshasbeendemonstratedforavarietyofmannosylatedlipidconjugatesinavarietyofliposomemorphologiesandcompositionsinseveraldifferent invitro and invivo models.Thereareseveralpublicationsusingahydrophobicderivativeofmannose(4-aminophenylα-D-mannopyranoside) ratherthanusingamannosylatedlipidinClodronateliposomes.Thisismainlyduetothehighcostandcomplexityofsynthesizingandconjugatingmannosetolipid. 4-aminophenylα-D-mannopyranosideiscommerciallyavailableandfarlessexpensivethansynthesizingmannoseconjugatedlipid.Whymannose?Mannoseisoneofthecarbohydratecomponentsofmanybacterialandviralcellsurfaces;therefore,theever-efficient,highlyredundantimmunesystemhasevolvedmultiplemechanismsforidentifyingpathogensbasedonmannoserecognition.Theanimalandplantkingdomslikewiseutilizecarbohydraterecognitionsignalingmechanismsincludingmannoseresidues.Manypublicationsevaluateothercarbohydratesastargetingmechanismsforvariouscelltypes,howevermannosetargetingtophagocytesappearstobeoneofthemorespecificmechanismsidentifiedtodate.Mammaliancellsurfaceidentificationmoleculesbasedonmannosebinding,suchastheICAMfamilyofleukocyteadhesionmolecules,targettheSIGNfamilyofmannosereceptorstoaccomplishself-recognition invivo.Awell-knownandcitedstudybyUmezawa&Eto [1]demonstratesthatliposomescontainingaminophenylmannosideweremostefficientlyincorporatedintothemousebrainacrossthebloodbrainbarrier.TherADIolabeledliposomesbearingaminophenyl
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~0.13µm- Suncoast Yellow Magnetic Microspheres - Encapsulated Fluorescent
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nanosoftpolymers/Cholesterol-PEG-NH2/3036-1000-500mg/500mg
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Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. - PubMed.cn
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