产品说明
Adenosine triphosphate (ATP) is the most abundant and primary carrier of the required energy for various functions in cells. Prolonged ischemia, reperfusion, anaerobic metabolism and lactate accumulation can lead to a dramatic decrease of ATP, cell swelling, cell rupture, and finally cell death by necrotic, necroptotic, apoptotic, and autophagic mechanisms. Due to drastic hydrolysis of ATP in vivo by ectoenzymes and poor cellular penetration, the direct delivery of ATP to the ischemic tissues is difficult.To increase delivery of ATP to the tissues and protect from enzymatic degradation, encapsulation in liposomes has been proposed and demonstrated in various models of ischemia [1,2]. Studies on myocardial [1,3,4], liver [5-8], retina [9] and wound healing [10-12] ischemia have shown the ability of liposomal encapsulated ATP to prevent cell death and tissue dysfunction following ischemic events.The encapsulation of ATP in liposomes markedly promotes its effectiveness by preventing the hydrolysis by extracellular enzymes, increasing ATP circulation time and enhancing its intracellular penetration. Depending on the type of the cell line and the target organ various types of liposomes with different surface charges such as anionic, cationic and neutral has been studied by various groups. Moreover, ATP encapsulated liposomes has been demonstrated to improve energy state and function of the cold-stored liver [6,7,13].
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文章排行榜
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~0.13µm- Suncoast Yellow Magnetic Microspheres - Encapsulated Fluorescent
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nanosoftpolymers/Cholesterol-PEG-NH2/3036-1000-500mg/500mg
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Innova Biosciences/High Throughput Colorimetric ATPase Assays (inc. PiColorLock)/601-0120/192 assays
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动物活体成像实验
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2017年05月纳米医学研究精选
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2017年6月博奥森(Bioss)抗体产品文献引用精选
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Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. - PubMed.cn
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Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice. - PubMed.cn
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SCI论文写作常用句型(二)EditSprings艾德思
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BILEAF Encapsula NanoSciences进口采购 Encapsula NanoSciences一级代理
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