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Encapsula/Non-PEGylated Magnetic Liposomes/2-ml/MAT-302

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MAT-302

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4000-520-616

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Adenosinetriphosphate(ATP)isthemostabundantandprimarycarrieroftherequiredenergyforvariousfunctionsincells.Prolongedischemia,reperfusion,anaerobicmetabolismandlactateaccumulationcanleadtoadramaticdecreaseofATP,cellswelling,cellrupture,andfinallycelldeathbynecrotic,necroptotic,apoptotic,andautophagicmechanisms. DuetodrastichydrolysisofATP invivo byectoenzymesandpoorcellularpenetration,thedirectdeliveryofATPtotheischemictissuesisdifficult.ToincreasedeliveryofATPtothetissuesandprotectfromenzymaticdegradation,encapsulationinliposomeshasbeenproposedanddemonstratedinvariousmodelsofischemia[1,2]. Studiesonmyocardial[1,3,4], liver[5-8], retina[9] andwoundhealing[10-12] ischemiahaveshowntheABIlityofLiposomalencapsulatedATPtopreventcelldeathandtissuedysfunctionfollowingischemicevents.TheencapsulationofATPinliposomesmarkedlypromotesitseffectivenessbypreventingthehydrolysisbyextracellularenzymes,increasingATPcirculationtimeandenhancingitsintracellularpenetration.Dependingonthetypeofthecelllineandthetargetorganvarioustypesofliposomeswithdifferentsurfacechargessuchasanionic,cationicandneutralhasbeenstudiedbyvariousgroups.Moreover,ATPencapsulatedliposomeshasbeendemonstratedtoimproveenergystateandfunctionofthecold-storedliver[6,7,13].