产品说明
liposomesareextensivelyusedtostudytheinteractionofproteins,peptidesandothermoleculeswiththesurfaceofalipidmembrane.OneoftheparametersthataffectsthisinteractionisthechargeoftheLiposomalmembrane.Liposomesarealwaysmadeinaqueousenvironmentandtheyaresizedtothedesiredsizeinliquidstateusingvariousmethodssuchashigh-pressureextrusionthroughnanosizedporetracketchmembranes.Liposomewithoutwaterismeaningless.Inrareoccasions,liposomesarefreezedriedandproliposomesareformedinthepresenceofalyoprotectantsuchastrehalose.Usingalyoprotectantisnecessaryinordertomaintainthesizeoftheliposomesafterrehydration.Thefundamentalstructureofcellmembranesisbilayerscomposedofphospholipids,andthevitalfunctionofthephospholipidsinthemembraneistohelpkeepitfluidandsemi-permeable.Conventionalglycerophospholipidshaveacylchainsattachedtothesn-1andsn-2positionsoftheglycerolbackboneviaanesterbond.Etherlipidsareauniqueclassofglycerophospholipidsthathaveanalkylchainattachedtothesn-1positionbyanetherbond(glycerol-etherlipids). Inetherlipids,thealcoholgroupattachedtothephosphateisgenerallycholineorethanolamine.Ether-linkedphospholipidssuchas1-alkyl-2-acyl-phosphatidylcholineanddialkylphosphatidylcholinearealsofoundintheplasmaandorganellemembranesofmammalianspecies.Etherlipidsformapproximately20%ofthetotalphospholipidinmammalswithdifferenttissuedistribution;brain,heart,spleenandwhitebloodcellshavethehighestlevels,whileliverhaveaverylittleamountofetherlipids.StudiesontheformationandThermodynamicpropertiesofether-linkedphospholipidbilayermembraneshaveindicatedthatincontrasttoester-linkedphospholipid,theformationofthenon-bilayerstructuretakesplacespontaneously.Thisisattributedtotheweakerinteractionbetweenpolarheadgroupsintheether-linkedthanthatintheester-linkedphospholipids.Ithasalsoshownthatthephasebehavioroftheether-linkedphospholipidbilayermembranesinambientpressureisalmostequivalenttothatoftheester-linkedphospholipidbilayermembranesunderhightemperaturesandpressures,andthedifferenceinthephasebehaviordecreaseasthealkyl-chainlengthincreases.Duetodistinctivepropertiesofetherlipids,liposomesmadefrometherlipidsexhibitveryuniquecharacteristicsandperformance:a)theetherbondsaremorestablethanesterlinkagesoverawiderangeofacidicoralkalinepH;b)stABIlitypropertiesoftheliposomesisenhancedbybipolarlipids,andthesaturatedalkylchainsgivesstabilitytowardsdegradationinoxidativeconditions;c)theunusualstereochemistryoftheglycerolbackboneenhancetheresistanceagainsttheattacksbyotherorganismphospholipases.Lyophosome™productcatalogiscomposedofalargeselectionoffreeze-driedliposomeswithvarioustypesoflipidsandwiderangeofzetapotentialsanddifferentproperties. Lyophosome™productsshouldbeusedbyscientistswhounderstandliposomeformulationandhavetheproperequipmenttocheckthesize,separatenon-encapsulateddrugsanddotheproperassays.Freeze-driedliposomescannotbeusedblindly.PhospholipaseA2(PLA2)cannothydrolyzetheetherlipidliposomes.Dietherlipidsdonotgothroughhydrolysisduetohavinganetherbondinsteadofanacylbondandthereforetodothat,theyareasuitablecandidateforexperimentsthatneedstobeperformedatahighertemperatureforanextendedperiodoftime. Formoreinformationabouthydrolysisandoxidationofphospholipidssee here.ThestructureofDOPCcontainingdiesterbondandpronetohydrolysis.Thestructureof18:1dietherlipidwhichcannotbehydrolyzed.Saturateddietherlipidscanneitherbehydrolyzednoroxidized.Thestructureof18:0dietherlipidwhichcanneitherbehydrolyzednoroxidized.
新品排行榜
1
Encapsula/Neutral Fluoroliposome...
2
Encapsula/Cellsome® – Phosphatid...
3
Encapsula/Lyophosome™ made from ...
4
Encapsula/ImmunoFluor™-Dodecanyl...
5
Encapsula/Cationic Liposome (Gen...
6
Encapsula/Fluorescent Phosphatid...
7
Encapsula/Neutral Fluoroliposome...
8
Encapsula/Lyophosome™ – Phosphat...
9
Encapsula/Cellsome® made from Na...
10
Encapsula/Fluorescent Phosphatid...
文章排行榜
1
~0.13µm- Suncoast Yellow Magnetic Microspheres - Encapsulated Fluorescent
2
nanosoftpolymers/Cholesterol-PEG-NH2/3036-1000-500mg/500mg
3
Innova Biosciences/High Throughput Colorimetric ATPase Assays (inc. PiColorLock)/601-0120/192 assays
4
动物活体成像实验
5
2017年05月纳米医学研究精选
6
2017年6月博奥森（Bioss）抗体产品文献引用精选
7
Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. - PubMed.cn
8
Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice. - PubMed.cn
9
SCI论文写作常用句型（二）EditSprings艾德思
10
BILEAF Encapsula NanoSciences进口采购 Encapsula NanoSciences一级代理
微信公众号
手机扫码，关注动态