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Ancell/anti-CD252(OX40L)/100 g/400-020

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Human CD252 (CD134L, OX40 Ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134(OX40) present on activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection (5,6,7,8). Isotype: Murine IgG1 KappaImmunogen: Human HUVEC and Recombinant soluble human CD252Specificity: Antibody ANC10G1 binds to CD252 on the cell surface of HUVEC in Flow cytometry, and blocks binding of recombinant CD134-muIg.Functional Application: Antibody ANC10G1 blocks binding of Recombinant CD134 to CD134L on HUVEC.References:1) W. R. Godfrey, et al, (1994) J Exp Med 180: 757-763.2)L.M. Higgins, et al, (1999) J Immunol 162: 486-493.3) A.D. Weinberg, et al, (1999) J Immunol 162: 1818-1826.4) V.Y. Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627.5) V. Malmstrom, et al, (2001) J Immunol 166: 6972.6) C. Nohara, et al, (2001) J Immunol 166: 2108-2115.7) X. Yuan, et al, (2003) J Immunol 170: 2949-2955.8) L. Tian, et al, (2002) Transplantation 74(1): 133-138.9) T Uenotsuchi, M Furue, et al. (2006) Intl Immunol 18(12): 1637-1646.

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