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Ancell/anti-CD105/120 tests/326-050

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Human CD105 (endoglin) is a homodimeric membrane glycoprotein (1) virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-b1 and b3 with high affinity (4).Isotype: Murine IgG1 kappaImmunogen: Membrane preparation of human B-lineage leukemia cellsSpecificity: Antibody SN6 recognizes an extracellular epitope of the human CD105 homodimer with a molecular weight of about 160 kd. It has been reported to cross react with non human Primate as well as Equine and Porcine(11) CD105.Functional Application: Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells. Antibody SN6 has been used to identify mesenchymal progenitor cells populations (8,9,10).References:1. Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA 83: 7898-7902.2. H. Hara, et al, (1988) Cancer Res 48: 4673-4680.3. W.C. Biddle, et al, (1989) Leukemia Res 13: 699-707.4. S. Cheifetz, et al, (1992) J Biol Chem 267: 19027-19030.5. B.K. Seon, et al, (1995) Proc Am Assoc Can Res 36: 23.6. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764.7. B.K. Seon, et al, (1996) Tissue Antigens 48: 417.8. S Alsalameh, M Lotz, et al. (2004) Arthritis & Rhematism 50(5): 1522-1532.9. A Banas, T Ochiya, et al. (2007) Hepatology 46: 219-228.10. R Williams, HE McCathy, et al. (2010) PLoS ONE 5(10): e13246 doi:10.1371.11. G Vilahur, L Badimon, et al. Oct 13, 2014 Toxicol Pathol pii: 0192623314551971.12. M Vigano, de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.

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