Product DetailsRecommended AssayReferencesDescriptionBcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is expressed in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5" splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. The Bcl-xS polypeptide shows a deletion of 63 amino acids which consist of the region of Bcl-xL with the highest degree of amino acid identity to Bcl-2. Like Bcl-2, Bcl-xL inhibits cell death upon growth factor withdrawal when transfected into an IL-3-dependent cell line. However, Bcl-xS inhibits Bcl-2 mediated cell survival.Format FormatPurifiedSuggested Companion ProductsHuman Endothelial Cell Lysate RUO 500µgCat No: 611450 HRP Goat Anti-Mouse Ig RUO 1mLCat No: 554002 FITC Goat Anti-Mouse Ig PolyclonalRUO 0.5mgCat No: 554001 Resources & ToolsSpectrumViewerDownload TDSRegulatory Document WebsitePreparation and StorageThe monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.Product NoticesSince applications vary, each investigator should titrate the reagent to obtain optimal results.Please refer to www.bdbiosciences.com/pharmingen/protocols for technical protocols.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.Source of all serum proteins is from USDA inspected abattoirs located in the United States.Anderson JS, Teutsch M, Dong Z, Wortis HH. An essential role for Bruton"s [corrected] tyrosine kinase in the regulation of B-cell apoptosis. Proc Natl Acad Sci U S A. 1996; 93(26):10966-10971.View referenceDevarajan P, De Leon M, Talasazan F, Schoenfeld AR, Davidowitz EJ, Burk RD. The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways. J Biol Chem. 2001; 276(44):40599-40605.View referenceKishimoto H, Sprent J. Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+ T cells. J Immunol. 1999; 163(4):1817-1826.View referenceOetzel C, Jonuleit T, Gotz A, et al. The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X. Clin Cancer Res. 2000; 6(5):1958-1968.View referenceSoini Y, Kinnula V, Kaarteenaho-Wiik R, Kurttila E, Linnainmaa K, Paakko P. Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma. Clin Cancer Res. 1999; 5(11):3508-3515.View reference
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Rat Granulocytes Pure RP-1 500ug |
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550002 | BD | Ms Ig Kpa Lgt Chain FITC 187.1 500ug |
550007 | BD | ICC Fixation Buffer 100mL |
550011 | BD | Ms CD210 NALE 1B1.3a 500ug |
550019 | BD | Ms CD51 Pure RMV-7 100ug |
550026 | BD | Ms CD5 APC 53-7.3 100ug |
550037 | BD | Hu CD62E PE-Cy5 68-5H11 100Tst |
550041 | BD | Hu CD95 Pure EOS9.1 100ug |
550052 | BD | Ham IgG2 Kpa ItCl FITC B81-3 250ug |
550057 | BD | Ms Crry/p65 Pure 1F2 100ug |
550059 | BD | Ms IL-4 Recom Protein 10ug |
550068 | BD | Ms IL-2 Recom Protein 20ug |
550070 | BD | Hu IL-6 Recom Protein 10ug |
550072 | BD | Hu MIP-1 Bta PE D21-1351 100ug |
550082 | BD | Ms IgG1 PE A85-1 100ug |
550084 | BD | Ham IgG2 Kpa ItCl PE B81-3 100ug |
550086 | BD | Hu CD142 Pure HTF-1 100ug |
550254 | BD | Hu CD1d PE CD1d42 100Tst |
550256 | BD | Hu CD73 PE AD2 100Tst |
550258 | BD | Hu CD103 FITC Ber-ACT8 100Tst |
550260 | BD | Ms CD11c APC HL3 100ug |
550268 | BD | Ms CD72b/c Aloatg PE JY/93 100ug |
550270 | BD | Rat CD32 Pure D34-485 500ug |
550272 | BD | Rat CD32 NALE D34-485 500ug |
550274 | BD | Ms CD3e IHC Pure 145-2C11 1mL |
550277 | BD | Ms CD4 IHC Pure H129.19 1mL |
550280 | BD | Ms CD8a IHC Pure 53-6.7 1mL |
