Product DetailsRecommended AssayReferencesDescriptionApoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1β converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.Format FormatPurifiedSuggested Companion ProductsHeLa Cell Lysate RUO 500µgCat No: 611449 HRP Goat Anti-Mouse Ig RUO 1mLCat No: 554002 FITC Goat Anti-Mouse Ig PolyclonalRUO 0.5mgCat No: 554001 Resources & ToolsSpectrumViewerDownload TDSRegulatory Document WebsitePreparation and StorageThe monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.Product NoticesSince applications vary, each investigator should titrate the reagent to obtain optimal results.Please refer to www.bdbiosciences.com/pharmingen/protocols for technical protocols.Source of all serum proteins is from USDA inspected abattoirs located in the United States.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.Duckett CS, Nava VE, Gedrich RW. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J. 1996; 15(11):2685-2694.View referenceLee Y, Shacter E. Fas aggregation does not correlate with Fas-mediated apoptosis. J Immunol. 2001; 167(1):82-89.View referenceReffey SB, Wurthner JU, Parks WT, Roberts AB, Duckett CS. X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. 2001; 276(28):26542-26549.View referenceWang GQ, Gastman BR, Wieckowski E. Apoptosis-resistant mitochondria in T cells selected for resistance to Fas signaling. J Biol Chem. 2001; 276(5):3610-3619.View referenceYang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science. 2000; 288(5467):874-877.View reference
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Rat Granulocytes Pure RP-1 500ug |
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550002 | BD | Ms Ig Kpa Lgt Chain FITC 187.1 500ug |
550007 | BD | ICC Fixation Buffer 100mL |
550011 | BD | Ms CD210 NALE 1B1.3a 500ug |
550019 | BD | Ms CD51 Pure RMV-7 100ug |
550026 | BD | Ms CD5 APC 53-7.3 100ug |
550037 | BD | Hu CD62E PE-Cy5 68-5H11 100Tst |
550041 | BD | Hu CD95 Pure EOS9.1 100ug |
550052 | BD | Ham IgG2 Kpa ItCl FITC B81-3 250ug |
550057 | BD | Ms Crry/p65 Pure 1F2 100ug |
550059 | BD | Ms IL-4 Recom Protein 10ug |
550068 | BD | Ms IL-2 Recom Protein 20ug |
550070 | BD | Hu IL-6 Recom Protein 10ug |
550072 | BD | Hu MIP-1 Bta PE D21-1351 100ug |
550082 | BD | Ms IgG1 PE A85-1 100ug |
550084 | BD | Ham IgG2 Kpa ItCl PE B81-3 100ug |
550086 | BD | Hu CD142 Pure HTF-1 100ug |
550254 | BD | Hu CD1d PE CD1d42 100Tst |
550256 | BD | Hu CD73 PE AD2 100Tst |
550258 | BD | Hu CD103 FITC Ber-ACT8 100Tst |
550260 | BD | Ms CD11c APC HL3 100ug |
550268 | BD | Ms CD72b/c Aloatg PE JY/93 100ug |
550270 | BD | Rat CD32 Pure D34-485 500ug |
550272 | BD | Rat CD32 NALE D34-485 500ug |
550274 | BD | Ms CD3e IHC Pure 145-2C11 1mL |
550277 | BD | Ms CD4 IHC Pure H129.19 1mL |
550280 | BD | Ms CD8a IHC Pure 53-6.7 1mL |
