Product DetailsRecommended AssayReferencesDescriptionAcute promyelocytic leukemia (APL) is characterized by the translocation of the retinoic acid receptor (RAR) gene on chromosome 17q21 with the promyelocytic leukemia (PML) gene on chromosome 15q22, resulting in t(15;17). The chimeric PML-RARα receptor protein retains essential functional domains encoded by the two genes. PML-RARα blocks cellular differentiation, thereby inducing leukemogenesis. All-trans-retinoic acid (ATRA) induces differentiation of APL cells. It is thought that ATRA promotes PML-RARα degredation which allows differentiation to progress. ATRA-induced differentiation of APL cells involves the coordinated regulation of many genes. NB4, a cell line derived from an APL patient, expresses RIG-G (Retinoic acid Induced Gene G) protein following treatment with ATRA or IFN-α. RIG-G displays strong homology to the protein products of the IFN-stimulated gene (ISG) family and contains multiple sites for post-translational modification. However, these sites remain to be fully characterized. Thus, RIG-G may be a component of ATRA and IFN signaling pathways that mediate cellular differentiation and the avoidance of leukemogenesis.Format FormatPurifiedSuggested Companion ProductsFITC Goat Anti-Mouse Ig PolyclonalRUO 0.5mgCat No: 554001 Human Endothelial Cell Lysate RUO 500µgCat No: 611450 HRP Goat Anti-Mouse Ig RUO 1mLCat No: 554002 Resources & ToolsSpectrumViewerDownload TDSRegulatory Document WebsitePreparation and StorageThe monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.Product NoticesSince applications vary, each investigator should titrate the reagent to obtain optimal results.Please refer to www.bdbiosciences.com/pharmingen/protocols for technical protocols.Source of all serum proteins is from USDA inspected abattoirs located in the United States.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.Inohara N, del Peso L, Koseki T, Chen S, Nunez G. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J Biol Chem. 1998; 273(20):12296-12300.View referenceInohara N, Koseki T, Lin J. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 2000; 275(36):27823-27831.View referenceMcCarthy JV, Ni J, Dixit VM. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. J Biol Chem. 1998; 273(27):16968-16975.View referenceNavas TA, Baldwin DT, Stewart TA. RIP2 is a Raf1-activated mitogen-activated protein kinase kinase. J Biol Chem. 1999; 274(47):33684-33690.View reference
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Rat Granulocytes Pure RP-1 500ug |
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550002 | BD | Ms Ig Kpa Lgt Chain FITC 187.1 500ug |
550007 | BD | ICC Fixation Buffer 100mL |
550011 | BD | Ms CD210 NALE 1B1.3a 500ug |
550019 | BD | Ms CD51 Pure RMV-7 100ug |
550026 | BD | Ms CD5 APC 53-7.3 100ug |
550037 | BD | Hu CD62E PE-Cy5 68-5H11 100Tst |
550041 | BD | Hu CD95 Pure EOS9.1 100ug |
550052 | BD | Ham IgG2 Kpa ItCl FITC B81-3 250ug |
550057 | BD | Ms Crry/p65 Pure 1F2 100ug |
550059 | BD | Ms IL-4 Recom Protein 10ug |
550068 | BD | Ms IL-2 Recom Protein 20ug |
550070 | BD | Hu IL-6 Recom Protein 10ug |
550072 | BD | Hu MIP-1 Bta PE D21-1351 100ug |
550082 | BD | Ms IgG1 PE A85-1 100ug |
550084 | BD | Ham IgG2 Kpa ItCl PE B81-3 100ug |
550086 | BD | Hu CD142 Pure HTF-1 100ug |
550254 | BD | Hu CD1d PE CD1d42 100Tst |
550256 | BD | Hu CD73 PE AD2 100Tst |
550258 | BD | Hu CD103 FITC Ber-ACT8 100Tst |
550260 | BD | Ms CD11c APC HL3 100ug |
550268 | BD | Ms CD72b/c Aloatg PE JY/93 100ug |
550270 | BD | Rat CD32 Pure D34-485 500ug |
550272 | BD | Rat CD32 NALE D34-485 500ug |
550274 | BD | Ms CD3e IHC Pure 145-2C11 1mL |
550277 | BD | Ms CD4 IHC Pure H129.19 1mL |
550280 | BD | Ms CD8a IHC Pure 53-6.7 1mL |
