首页 > Stemrd > Stemrd/SB431542, ALK-4, -5, -7 Inhibitor/50 mg/SB-050

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Stemrd/SB431542, ALK-4, -5, -7 Inhibitor/50 mg/SB-050

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SB-050

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SourceM.W.384.39CAS No.301836-41-9Structural Info4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDEFormulationPowderReconstitutionBefore reconstitution, werecommend a brief spin to drive down any material dislodged from the bottom ofthe tube. The compound is soluble inDMSO.StabilityThe powder is stable for atleast 2 year if stored at -20°C. The dissolved compound is stable for at least 1 month at 4 °C, butshould be stored in aliquots at -20 °C for longer term. Protect from light.PurityGreater than 98% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request.Biological ActivityCountry of OriginUSAA selectiveinhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50= 94 nM), and the related ALK4 and ALK7.Ref: Lapinget al. Inhibition of transforming growth factor (TGF)-β1-inducedextracellular matrix with a novel inhibitor of the TGF-β type I receptor kinaseactivity: SB-431542. Mol.Pharmacol. 62 58, 2002. Inmanet al. SB-431542 is a potent and specific inhibitor of transforminggrowth factor-β superfamily type I activin receptor-like kinase (ALK) receptorsALK4, ALK5, and ALK7. Mol.Pharmacol. 62 65, 2002.Product Sheet

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