首页 > JPT > JPT/CEF Pool (extended) (120nmol; >70%)/PM-CEF-E-2/

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JPT/CEF Pool (extended) (120nmol; >70%)/PM-CEF-E-2/

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PM-CEF-E-2

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CEFPool(extended)(120nmol;>70%)ProductCode:PM-CEF-E-2PositiveControlPoolof32peptidesselectedfromdefinedHLAclassI-restrictedT-cellepitopesforTcellassays(e.g.ELISPOT).Amount:1vialcontaining120nmol(appr.200µg)perpeptidePurity:>70%(HPLC-MS)DeliveryFormat:FreezedriedinambertypeglassvialApplication(s):T-cellassays,Immunemonitoring,AntigenspecificT-cellstimulation,T-cellexpansion,CellularimmuneresponseIndication(s)/Topic(s):ControlDeliveryTime:2-5daysPepMixes™PeptidePoolsTheuseofcompleteprotein-spanningmixturesofoverlappingpeptides(PepMix™)isextremelyefficientforimmunostimulationofT-lymphocytesanddiagnosticapplications.InordertoestablishreliableandvalidatedT-cellassayssuchasELISPOT,appropriatepositiveandnegativecontrolsareessential.SelectionofsuchcontrolshelpstoconfirmproperfunctionalityoftheassayaswellasviABIlityofthecellsused.Inaddition,highqualitycontrolsaremostimportanttoestablishstandardizedassayprotocolsinclinicalsetups.Comparedtocommonlyusedcontrolslikephytohemagglutinin(PHA)andconcanavalinA(ConA)thatstimulateT-cellsaswellasothercelltypesorfulllengthantigens,syntheticpeptidepoolsoffertheadvantageofahighbatch-to-batchreproducibility,applicabilityofreliablechemicalandbiochemicalQC/QAmeasuresandshelfstabilitywhenstoredasfreezedriedaliquots.BenefitsofPepMix™-EquivalentorbetterstimulationofCD4+andCD8+T-cellresponsescomparedtowholeproteinantigens-SimultaneousdetectionofCD4+andCD8+responsesinasinglesample-ImprovedresponsesinstoredbloodandPBMcellscomparedtowholeproteinantigens-Morereliableascontrolthanphytohemagglutinin(PHA)andconcanavalinA(ConA)-High-batch-to-batchreproducibility-Reliablechemicalandbiochemicalqualitycontrolandqualityassuranceforpeptidesynthesisandpeptidepoolgeneration-ProlongedshelfstabilitywhenstoredfreezedriedCEFPool(extended)(120nmol;>70%)SelectedReferences"StandardizationofCryopreservedPeripheralBloodMononuclearCellsThroughaRestingProcessforClinicalImmunomonitoring?DevelopmentofanAlgorithm"Wangetal.,CytometryA.(2015)-PMID:26848928"DichotomousEffectsofLatentCMVInfectiononthePhenotypeandFunctionalPropertiesofCD8+T-cellsandNK-cells"Bigleyetal.,CellularImmunology(2015)-PMID:n.a"K562-DerivedWhole-CellVaccineEnhancesAntitumorResponsesofCAR-RedirectedVirus-SpecificCytotoxicTLymphocytesInVivo"Caruanaetal.,ClinCancerRes.(2015) -PMID:25691731"Self-adjuvantedmRNAVaccinationinAdvancedProstateCancerPatients:aFirst-in-ManPhaseI/IIaStudy"Kübleretal.,JImmunotherCancer.(2015)-PMID:26082837"GuidelinesFortheAutomatedEvaluationofElispotAssays"Janetzkietal.,NatureProtocols(2015)-PMID:26110715"ProfilingTCellActivationUsingSingle-MoleculeFluorescenceInSituHybridizationandFlowCytometry"Bushkinetal.,J.Immunol.(2015)-PMID:25505292ApplicationNotes"DevelopingMulti-HIVAntigenSpecificT-CellsasaComponentofaCureStrategy"Lametal.(2015)Fulltext"Peptide-stimulatedExpansionofVirus-specificTcellsForPreventativeTreatmentAfterAllogeneicStemCellTransplantation"Garyetal.(2015)FulltextCEFPool(extended)(120nmol;>70%)TechnicalData:ApplicationAntigenspecificT-cellstimulationImmunemonitoringT-cellassaysT-cellexpansionProteinNameSelectedproteinsOrganismEpstein-Barrvirus(HHV-4)Humancytomegalovirus(HHV-5)InfluenzaAIndication/TopicControlNumberofpeptides32 FurtherInformation:Amount1vialcontaining120nmol(appr.200µg)perpeptideSpecificationsDefinedHLAclassI-restrictedT-cellepitopesDocumentationProtocolandDatasheetSequenceSeeProductDatasheetunderProductDocumentation

JPT的关键技术平台基于该公司强大而长期的技术，化学和生物学背景。JPT已经开发了几种独特的方法，可解决细胞疗法和疫苗开发过程的所有阶段，包括生物标记物发现，新表位优先，免疫监测和疫苗功效测试。
此外，这四个技术平台为靶向蛋白质组学和分子诊断奠定了基础。JPT的技术在需要进行肽筛查的领域中得到了广泛的应用。典型示例包括：筛选蛋白肽，酶活性（蛋白酶，激酶，磷酸酶，甲基转移酶）或肽前导结构的系统优化。