首页 > JPT > JPT/NB Histone Peptide H4 1:17 R3me1_K5ac (H4)/SP-His_nb_145/

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JPT/NB Histone Peptide H4 1:17 R3me1_K5ac (H4)/SP-His_nb_145/

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SP-His_nb_145

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NBHistonePeptideH41:17R3me1_K5ac(H4)ProductCode:SP-His_nb_145SyntheticHistonepeptidecarrying2modifications(R3me1,K5ac)derivedfromhumanHistoneH4(Swiss-ProtIDs:P62805).Aminoacidsequence:H-SG-Arg(Me)-G-Lys(Ac)-GGKGLGKGGAKR-NH2Amount:1vialcontaining30nmol(approx.100µg)Purity:>70%(HPLC-MS)Deliveryformat:Freeze-driedinambertypeglassvialsApplication(s):Enzymekinetics,SubstrateSpecifity,Substrateidentification,Competitionexperiments,Co-crystallization,NMRstudiesIndication(s)/Topic(s):Cancer,Kinase,Methyltransferase,Acetyltransferase,Histones,Phosphatase,Generegulationandexpression,Epigenetics,Cellsignaling,NucleosomeDeliverytime:10-12daysJPT"sNon-BiotinylatedHistoneCodePeptidesInadditiontoourbiotinylatedhistonepeptides,JPToffersanon-biotinylatedlibraryofsyntheticposttranslationallymodifiedandunmodifiedhumanhistonepeptidesthatisnowavailableasindividualpeptides.Thepeptidelibraryconsistsof160peptidesfromdifferenthistonefamilies.PeptidescarryPTMsatreportedsites(e.g.acetylation,methylation,phosphorylation...)invariouscombinationsrepresentingnaturalvariants.JPT"shighlyskilledandcommittedscientificstaffensuresthatthemostappropriatemethodsandtechniquesareselectedforeverysynthesisproject.AllofJPT"scatalogpeptidesareprovidedwithHPLC-MSanalysestoconfirmtheidentityanddemonstratethehighqualityofourpeptides.BenefitsofJPT"sHistoneCodePeptides-WholeproductionperformedinaregulatedEuropeanenvironmentaccordingtoDINENISO9001:2015&GCLPstandards;auditswelcome!-Forhigh-throughputscreeningJPT"sHistoneCodePeptideMicroarrayisavailabledisplayingmorethan3000peptides.-ProvisionoffreezedriedaliquotsforenhancedstABIlity-ProventrackrecordformanyapplicationsNBHistonePeptideH41:17R3me1_K5ac(H4)SelectedReferencesforHistonePeptideTools"HistoneH2AandH4N-TerminalTailsarePositionedbytheMEP50WD-RepeatProteinforEfficientMethylationbythePRMT5ArginineMethyltransferase"Burgosetal.,J.Biol.Chem.(2015)-PMID:25713080"H3K23me2isaNewHeterochromaticMarkinCaenorhaBDitiselegans"Vandammeetal., NucleicAcidsRes.(2015)-PMID:26476455"StructureoftheArginineMethyltransferasePRMT5-MEP50RevealsaMechanismforSubstrateSpecificity"Hoetal.PLOSONE(2013)-PMID:23451136"UseofHigh-DensityHistonePeptideArraysforParsingtheSpecificityofaHistone-ModifyingEnzymeComplex"Shechteretal,ApplicationNote(2013)(fulltext)"ComprehensivePeptideMicroarraysforHistoneResearch"Schnatbaumetal,32thEPS(2012)(fulltext)ApplicationNotes"UseofHigh-DensityHistonePeptideArraysforParsingtheSpecificityofaHistone-ModifyingEnzymeComplex"Shechteretal.ApplicationNote(2013)(fulltext)"ComprehensiveCharacterizationofAntibodiesDirectedtowardsEpigeneticHistone-Modifications"Maschetal.ApplicationNote(2015)(fulltext)TestimonialforHistoneCodePeptideMicroarray"JPT"snewextremelyhigh-densityhistonepeptidearrayisadramaticleapforwardforanalysisofthehistonecodehypothesis.Thecompletesequencecoverageacrosscorehistonesandhistonevariantsaswellasthepresenceofcommonandrarehistonepost-translationalmodifications "aloneandincombination"makesthisanunparalleledtoolforstudyingthe"writers"and"readers"ofthehistonecode.MylaboratoryhasusedthesearraystoaskthesequenceandPTMdependenceofahistonewriterenzymeandwehavediscoveredanactivityspecifyingcodethatwillkeepusbusyforyearstocome."DavidShechter,PhD,DepartmentofBiochemistry,AlbertEinsteinCollegeofMedicine,YU(NY,USA)NBHistonePeptideH41:17R3me1_K5ac(H4)TechnicalData:HistoneFamilyHistoneH4Modification2ModificationsSequencePositionTail(1-42)IsoformH4BiotinylationNoBiotinApplicationSubstrateidentificationProteinNameHistonesOrganismHomosapiens(Human)Indication/TopicAcetyltransferaseEpigeneticsKinaseNumberofpeptides1 FurtherInformation:Amount1vialcontaining30nmol(approx.100µg)SpecificationsSyntheticHistonepeptidecarrying2modificationsDocumentationProductDatasheetSwiss-ProtIDP62805NCBISequenceH-SG-Arg(Me)-G-Lys(Ac)-GGKGLGKGGAKR-NH2

JPT的关键技术平台基于该公司强大而长期的技术，化学和生物学背景。JPT已经开发了几种独特的方法，可解决细胞疗法和疫苗开发过程的所有阶段，包括生物标记物发现，新表位优先，免疫监测和疫苗功效测试。
此外，这四个技术平台为靶向蛋白质组学和分子诊断奠定了基础。JPT的技术在需要进行肽筛查的领域中得到了广泛的应用。典型示例包括：筛选蛋白肽，酶活性（蛋白酶，激酶，磷酸酶，甲基转移酶）或肽前导结构的系统优化。