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JPT/PepMix AAV8 (capsid protein)/PM-AAV8-CP/

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PM-AAV8-CP

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PepMixAAV8(capsidprotein)ProductCode:PM-AAV8-CPPoolof182peptidesderivedfromapeptidescan(15merswith11aaoverlap)throughCapsidprotein(UniProtID:Q8JQF8)ofAdeno-associatedvirus8.Amount:1vialcontaining15nmol(appr.25µg)perpeptidePurity:>70%(HPLC-MS)DeliveryFormat:FreezedriedinambertypeglassvialApplication(s):T-cellassays,Immunemonitoring,AntigenspecificT-cellstimulation,T-cellexpansion,Cellularimmuneresponse,ELISPOT,ICS,Immunemonitoring,Proliferationassay,T-cellexpansionIndication(s)/Topic(s):Infection,GenetherapyDeliveryTime:2-5daysPepMix™PeptidePoolsTheuseofcompleteprotein-spanningmixturesofoverlappingpeptides(PepMix)isextremelyefficientforimmunostimulationofT-lymphocytesanddiagnosticapplications.InordertoestablishreliableandvalidatedT-cellassayssuchasELISPOT,appropriatepositiveandnegativecontrolsareessential.SelectionofsuchcontrolshelpstoconfirmproperfunctionalityoftheassayaswellasviABIlityofthecellsused.Inaddition,highqualitycontrolsaremostimportanttoestablishstandardizedassayprotocolsinclinicalsetups.Comparedtocommonlyusedcontrolslikephytohemagglutinin(PHA)andconcanavalinA(ConA)thatstimulateT-cellsaswellasothercelltypesorfulllengthantigens,syntheticpeptidepoolsoffertheadvantageofahighbatch-to-batchreproducibility,applicabilityofreliablechemicalandbiochemicalQC/QAmeasuresandshelfstabilitywhenstoredasfreezedriedaliquots.BenefitsofPepMix™-EquivalentorbetterstimulationofCD4+andCD8+T-cellresponsescomparedtowholeproteinantigens-SimultaneousdetectionofCD4+andCD8+responsesinasinglesample-ImprovedresponsesinstoredbloodandPBMcellscomparedtowholeproteinantigens-Morereliableascontrolthanphytohemagglutinin(PHA)andconcanavalinA(ConA)-High-batch-to-batchreproducibility-Reliablechemicalandbiochemicalqualitycontrolandqualityassuranceforpeptidesynthesisandpeptidepoolgeneration-ProlongedshelfstabilitywhenstoredfreezedriedPepMixAAV8(capsidprotein)SelectedReferences"InVitroStudiesoftheImpactofMaribavironCMV-SpecificCellularImmuneResponses"Stacheletal.,JClinVirol. (2015)-PMID:26780109"InductionOfBroad-basedImmunityandProtectiveEfficacybySelf-amplifyingmRNAVaccinesEncodingInfluenzaVirusHemagglutinin"Brazzolietal.,JournalofVirology (2015)-PMID:26468547"TargetingofNucleoproteintoChemokineReceptorsbyDNAVaccinationResultsinIncreasedCD8+-mediatedCrossProtectionAgainstInfluenza"Baranowskaetal.,Vaccine(2015)-PMID:26387432"CharacteristicsofImmuneMemory10-15yearsAfterPrimaryHepatitisBVaccination"Hummeletal.,Vaccine(2015)-PMID:n.a."TCellsSpecificforDifferentLatentandLyticViralProteinsEfficientlyControlEpstein-BarrVirusTransformedBCells"Nowakowskaetal.,Cytotherapy(2015)-PMID:26276009"High-densityPrecultureofPBMCsRestoresDefectiveSensitivityofCirculatingCD8TCellstoVirus-andTumor-derivedAntigens"Wegneretal.,Blood(2015)-PMID:26024876"MetabolicRegulationofHepatitisBImmunopathologybyMyeloid-derivedSuppressorCells"Pallettetal.,NatureMedicine(2015)-PMID:25962123ApplicationNotes"DevelopingMulti-HIVAntigenSpecificT-CellsasaComponentofaCureStrategy"Lametal.(2015)Fulltext"Peptide-stimulatedExpansionofVirus-specificTcellsForPreventativeTreatmentAfterAllogeneicStemCellTransplantation"Garyetal.(2015)FulltextTestimonials"Toestablishanovelroleformyeloidderivedsuppressorcells(Pallettetal,Nat.Med.2015)inchronicviralinfection,weutilisedthePepMixCEFPool(extended)aswellasacustomsynthesizedPepMixspanningthecoreregionofHBVgenotypeD.Whereas,theCEFpeptidepoolconsistsof32peptides,eachcorrespondingtoadefinedHLAclassI-restrictedT-cellepitopefromCytomegalo,Epstein-Barr,andInfluenzavirus,thelattercustomPepMixincluded15mericpeptidesoverlappingby10aminoacids.SpecificallythiscompositionenabledustomonitorboththeantiviralCD8+andCD4+TcellresponsesinchronicHBVinfectionandthenon-antigenspecificTcellsthatareknowntomediateimmunopathologyintheliver.OurentireexperiencewithJPT,fromordering/deliverytouseinthelabwasexcellent.Notonlywerethereagentsabletoperformreliablyandconsistentlyinvitrofrombatchtobatch,thecustomerandtechnicalsupportprovidedwascontinuallyavailableandefficientwhenneeded.JPTwillremainour"go-to"companyforpurchasingpeptides."Dr.LauraJPallett,InfectionandImmunity,UniversityCollegeLondon,UKPepMixAAV8(capsidprotein)TechnicalData:ApplicationAntigenspecificT-cellstimulationImmunemonitoringT-cellassaysT-cellexpansionProteinNameCapsidproteinOrganismAdeno-associatedvirusIndication/TopicCancerGenetherapyNumberofpeptides182 FurtherInformation:Amount1vial(15nmolperpeptide,appr.25ugperpeptide)SpecificationsPeptidescan(15merswith11aaoverlap)DocumentationProtocolandDatasheetSwiss-ProtIDQ8JQF8SequenceMAADGYLPDWLEDNLSEGIREWWALKPGAPKPKANQQKQDDGRGLVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLQAGDNPYLRYNHADAEFQERLQEDTSFGGNLGRAVFQAKKRVLEPLGLVEEGAKTAPGKKRPVEPSPQRSPDSSTGIGKKGQQPARKRLNFGQTGDSESVPDPQPLGEPPAAPSGVGPNTMAAGGGAPMADNNEGADGVGSSSGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISNGTSGGATNDNTYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLSFKLFNIQVKEVTQNEGTKTIANNLTSTIQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFQFTYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTQTTGGTANTQTLGFSQGGPNTMANQAKNWLPGPCYRQQRVSTTTGQNNNSNFAWTAGTKYHLNGRNSLANPGIAMATHKDDEERFFPSNGILIFGKQNAARDNADYSDVMLTSEEEIKTTNPVATEEYGIVADNLQQQNTAPQIGTVNSQGALPGMVWQNRDVYLQGPIWAKIPHTDGNFHPSPLMGGFGLKHPPPQILIKNTPVPADPPTTFNQSKLNSFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYYKSTSVDFAVNTEGVYSEPRPIGTRYLTRNLProteinLength(aa)738

JPT的关键技术平台基于该公司强大而长期的技术，化学和生物学背景。JPT已经开发了几种独特的方法，可解决细胞疗法和疫苗开发过程的所有阶段，包括生物标记物发现，新表位优先，免疫监测和疫苗功效测试。
此外，这四个技术平台为靶向蛋白质组学和分子诊断奠定了基础。JPT的技术在需要进行肽筛查的领域中得到了广泛的应用。典型示例包括：筛选蛋白肽，酶活性（蛋白酶，激酶，磷酸酶，甲基转移酶）或肽前导结构的系统优化。