首页 > Hycult Biotech > Hycult Biotech/Elastase, Human, ELISA kit | Hycult Biotech/HK319-02

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Hycult Biotech/Elastase, Human, ELISA kit | Hycult Biotech/HK319-02

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Neutrophil elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition, mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI.When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.In plasma of healthy individuals approx. 55 ng/ml (29 - 86 ng/ml) elastase is present.

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。