首页 > Hycult Biotech > Hycult Biotech/C4d, Mouse, pAb/HP8033/100 µg

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Hycult Biotech/C4d, Mouse, pAb/HP8033/100 µg

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HP8033

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Description:C4d,Mouse,pAbThepolyclonalantibodyrecognizesmouseC4d.ComplementfactorC4(MW41kDa),formerlyknownasGgprotein,consistsofanalpha-,beta-andgamma-chain.Theclassicalpathwayofcomplementandthemannosebindinglectin(MBL)activationpathwayconvergeatC4.ActivatedC1,MASP-1andMASP-2cleaveC4resultingintheformationofC4aandC4b.ThelattercanbecleavedbyfactorIresultinginC4candC4d,inwhichstepallfunctionalsitesarelost.TheC4dactivationfragmentofC4isanexcellentMarkerforclassicalcomplementpathwayandMBLpathwayactivation.ThethioesterformedbetweenthesidechainsofCys1010andGln1013withintheC4dregionoftheα-chainmediatescovalentattachmenttothetargetsurfacebearingactivatedformsofC1sorMASP.FurThermore,C4dishighlyhomologoustoC3dwithover35%sharedaminoacidsequence.Inanumberofdiseasessuchasrheumatoidarthritis(RA),hereditaryangioedema(HAE),systemiclupuserythematosus(SLE)andchronicurticariawithhypercomplementemialevelsofC4daresignificantlyelevatedinserumorplasma.C4dlevelsmayalsobeelevatedinplasmafrompatientswithavarietyofhumoralautoimmunediseasesinwhichcomplementactivationisknowntooccur.DepositionofC4dinperitubularcapillarieshasbeenshowntobeasensitivemarkerforantibody-mediated(humoral)rejectioninrenaltransplantbiopsies.Specifications:CatalognumberHP8033ProducttypePolyclonalantibodiesQuantity100µgFormulation1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.ApplicationFlowcytometry,Frozensections,Paraffinsections,WesternblotUseForimmunohistochemistry,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenAsynthesized14-merpeptide(RPTAPRSPTEPVPQ)correspondingtoaminoacids1223-1236ofmouseC4,conjugatedtokeyholelimpethemocyaninattheC-terminalpart(forthisacysteinewasadded)IsotypeRabbitIgSpeciesMouseReferences1.Murata,Ketal;SynergisticdepositionofC4dbycomplement-activatingandnon-activatingantibodiesincardiactransplants.AmJTransplant2007,7:26052.Jindra,Petal;Anti-MHCclassIantibodyactivationofproliferationandsurvivalsignalinginmurinecardiacallografts.JImmunol2008,180:22143.Morrell,Cetal;Invivoplatelet-endothelialcellinteractionsinresponsetomajorhistocompatibilitycomplexalloantibody.CircRes2008,102:777StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。