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Hycult Biotech/Spi-6, Mouse, pAb/HP8035/100 µg

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HP8035

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Description:Spi-6,Mouse,pAbThepolyclonalantibodyrecognizesmouseSpi-6,alsoknownasserpinB9,acytoplasmicserineproteaseinhibitorof~42kD.Spi-6isexpressedindendriticcells,lymphocytesandspecificcelltypesatimmune-privilegedsites.ItinactivatesgranzymeB,anaturaloccurringinducerofprogrammedcelldeath.Assuch,Spi-6functionsasanti-apoptoticprotein.IncytotxicTcells(CTL),Spi-6isrequiredtoprotectclonalbursts(expansion)fromgranzymeBinducedcelldeath.However,itisnotrequiredforthedevelopmentofmemorycells.ExpressionofSPI-6isofcrucialimportanceintheescapeofseveraltumorsfromaCTLresponseandis,therefore,aparameterthatinfluencesthefeasibilityofCTL-mediatedimmunotherapyofcancer.ThepolyclonalantibodyshowsnocrossreactivitywithmouseproteinsrelatedtoSpi-6.Specifications:CatalognumberHP8035ProducttypePolyclonalantibodiesQuantity100µgFormulation1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.ApplicationFlowcytometry,Immunoassays,WesternblotUseForflowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenRecombinantGST-Spi-6IsotypeRabbitIgSpeciesMouseAliasCytoplasmicantiproteinase3,serpinB9,PI-9References1.Zhang,Metal;DifferentialsurvivalofcytotoxicTcellsandmemorycellprecursors.JImmunol2007,178:34832.Zhang,Metal;Serineproteaseinhibitor6-deficientmicehaveincreasedneutrophilimmunitytoPseudomonasaeruginosa.JImmunol2007,179:4390StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseTumorimmunology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。