首页 > Hycult Biotech > Hycult Biotech/TNF-alpha, Human, mAb 52B83/HM2010/100 µg

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Hycult Biotech/TNF-alpha, Human, mAb 52B83/HM2010/100 µg

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Description:TNF-alpha,Human,mAb52B83Themonoclonalantibody52B83reactswithtumornecrosisfactoralpha(TNF-alpha).TNF-alphaisahomotrimeric17kDaprotein,thatinteractswitheitheroneofthetwotypesofTNF-receptors,termedIandII,leADIngtoreceptorcross-linkingandsignaltransduction.Thereceptorsdifferstronglyintheirintra-cellularsignalingpathways.TNF-alphawasoriginallydescribedasahighlycytotoxiccytokinefortumorcells,itcausestumornecrosisinvivoandshowscytolyticactivityagainsttumorcellsinvitro.FurThermore,-TNF-alphaisfoundtobeacentralmediatorinmanyinflammatoryandimmunologicalprocesses.Itcanbeinducedbyvariousproductsofmicro-organismsandbyvariouscytokinesleadingtoexpressionofawidevarietyof-cytokines.Thepro-inflammatorypropertiesof-TNF-alphaplayacentralroleinseveralauto-immunediseasessuchasrheumatoidarthritisandinhibitionbyneutralizingmoleculeshavebeenshowntobebeneficialinpatients.Specifications:CatalognumberHM2010ProducttypeMonoclonalantibodiesQuantity100µgFormulation1ml(100μg/ml)0.2μmfilteredproteinGpurifiedantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.ApplicationFlowcytometry,Frozensections,Immunoassays,WesternblotApplicationNotesFC:Antibody52B83wasusedtostainsolubleTNFboundtoTNFreceptors.CellswerefixedinPBAcontaining0.2%formaldehyde(Ref.3)W:Areducedsampletreatmentand15%SDS-Pagewasused.Thebandsizeobservedis17kDa(Ref.4).IHC-F:6-μmtissuesectionswerefixedinacetonefor10minutes(Ref.4).UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.IsotypeMouseIgG1SpeciesHumanCrossreactivityGuineapig-Yes,Mouse-Yes,Rhesusmonkey-YesAliasTumorNecrosisFactor-alpha,TNF,TNF-SF2,cachectinReferences1.Bradding,Petal;Interleukin-4,-5,and-6andTumorNecrosisFactor-alphainnormalandasthmaticairways:Evidenceforthehumanmastcellasasourceofthesecytokines.AmJRespirCellMolBiol1994,10:4712.Bradding,Petal:TNFalphaislocalizedtonasalmucosalmastcellsandisreleasedinacuteallergicrhinitis.ClinExpAllergy1995,25:4063.Gerspach,Jetal;Detectionofmembrane-boundTumorNecrosisFactor(TNF):ananalysisofTNF-specificreagents.MicroscResTech2000,50:2434.Laanvander,Netal;Tumornecrosisfactoralpha(TNFalpha)inhumanskin:acomparisonofdifferentantibodiesforimmunohistochemistry.ArchDermatolRes2001,293:2265.Lee,Eetal;Clinicalandimmunohistochemicalcharacteristicsofmucoceles.AnnDermatol2009,21:3456.Brunner,Petal;InfliximabinducesdownregulationoftheIL-12/IL-23axisin6-sulfo-LacNac(slan)1dendriticcellsandmacrophages.JAllergyClinImmunol2013,132:1184StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseAutoimmunity,Gastroenterology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。