首页 > Hycult Biotech > Hycult Biotech/CD46, Human, mAb M177, functional study antibody, low endotoxin/HM2103-FS/0.5 mg

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Hycult Biotech/CD46, Human, mAb M177, functional study antibody, low endotoxin/HM2103-FS/0.5 mg

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HM2103-FS

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Description:CD46,Human,mAbM177,functionalstudyantibody,lowendotoxinThemonoclonalantibodyM177recognizesCD46,alsodesignatedmembranecofactorprotein(MCP).CD46isa45-70kDaproteinwithgeneticandtissue-specificheterogeneity.-Itisexpressedoneverycellandtissue,withtheexceptionoferythrocytes.CD46servestoinhibitcomplementactivationonhosttissue.ItperformsthisfunctionbyservingasacofactorwhichbindstoC3bandC4b.ThisbindingispermittedbyfactorI,aserineproteaseofplasma,todegradeC3bandC4bandservestoprotectthehostcellagainstautologousattack.Italsoservesasareceptorformeaslesvirus.FourisoformsofCD46predominateandarisebyalternativesplicingofasingleCD46gene.CD46CDNAencodesasignalsequencefollowedbyfourcomplementcontrolproteindomains(alsocalledshortconsensusrepeats(SCR)).ThemonoclonalantibodyM177reactswiththeSCR2domain.Specifications:CatalognumberHM2103-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFlowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunoprecipitation,WesternblotApplicationNotesFC:AntibodyM177stainstheextracellulardomainofCD46.IP:107cellswerelysedandimmunoprecipitatedwith25 µgM177antibodyand25 µgproteinG-sepharoseW:Anon-reducedsampletreatmentandSDS-pagewasused.Thebandsizeis45-70kDa(Ref1and2).UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting.ImmunogenPurifiedMCPIsotypeMouseIgG1SpeciesHumanAliasMembranecofactorprotein,TLX,trophoblastleucocytecommonantigenGenename:CD46PositiveControlCD46isexpressedoneverycellandtissueNegativeControlErythrocytesReferences1.Seya,Tetal;Quantitativeanalysisofmembranecofactorprotein(MCP)ofcomplement.HighexpressionofMCPonhumanleukemiacelllines,whichisdown-regulatedduringcelldifferentiation.JImmunol1990,145:2382.Iwata,Ketal;DiversityofsitesformeaslesvirusbindingandforinactivationofcomplementC3bandC4bonmembranecofactorproteinCD46.JBiolChem1995,270:151483.Kurita-Taniguchi,Metal;FunctionalmodulationofhumanmacrophagesthroughCD46(Measlesvirusreceptor):productionofIL-12p40andnitricoxideinassociationwithrecruitmentofprotein-tyrosinephosphataseSHP-1toCD46.JImmunol2000,165:51434.Kurita-Taniguchi,Metal;MolecularassemblyofCD46withCD9,alpha3-beta1integrinandproteintyrosinephosphataseSHP-1inhumanmacrophagesthroughdifferentiationbyGM-CSF.MolImmunol2001,38:6895.Loré,Ketal;MyeloidandplasmacytoiddentriticcellsaresusceptIBLetorecombinantadenovirusvectorsandstimulatepolyfunctionalmemoryTcellresponses.JImmunol2007,179:17216.Adams,Wetal;AttenuationofCD4+T-cellfunctionbyhumanadenovirustype35ismediatedbytheknobprotein.JGenVirol2012,93:13397.Johnson,Metal;TypeIIFNInducedbyAdenovirusSEROtypes28and35HasMultipleEffectsonTCellImmunogenicity.JImmunol2012,188:61098.Teigler,Jetal;VaccinationwithAdenovirusSerotypes35,26,and48ElicitsHigherLevelsofInnateCytokineResponsesthanAdenovirusSerotype5inRhesusMonkeys.JVirol2012,86:95909.Abbink,Petal;ConstructionandEvaluationofNovelRhesusMonkeyAdenovirusVaccineVectors.JVirol2015,89:151210.Fujiyuki,Tetal;Ameaslesvirusselectivelyblindtosignalinglymphocyticactivationmoleculeshowsanti-tumoractivityagainstlungcancercells.Oncotarget2015,6:24895StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseInfectiousdiseases,Tumorimmunology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。