首页 > Hycult Biotech > Hycult Biotech/C1s, Human, mAb M81, functional study antibody, low endotoxin/HM2108-FS/0.5 mg

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Hycult Biotech/C1s, Human, mAb M81, functional study antibody, low endotoxin/HM2108-FS/0.5 mg

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HM2108-FS

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Description:C1s,Human,mAbM81,functionalstudyantibody,lowendotoxinMonoclonalantibodyM81reactswithanepitopeonhumanCproteinactivatedC1s,asubcomponentofthefirstcomponentofC(C1).ActivatedC1sisaglycosylatedsingle-polypeptidezymogen,MW85kD.ActivationoftheproenzymeC1soccursthroughcleavagebytheactiveformofC1r.Theactivatedprotease,activatedC1s,consistsofadisulfide-linkedHchainandaLchain.ActivatedC1sisaserineproteaseanditscatalyticsiteislocatedintheLchain.ActivationoftheclassicalCpathwayistriggeredbyactivatedC1swhichcleavesC4andC2toformtheC3convertase,C4bC2a.TheepitoperecognisedbytheantibodyM81isdomainIVand/orVofthegamma-domainofactivatedC1s.MonoclonalantibodyM81blocksC4activationandC4bindingtoactivatedC1s.TheantibodyreactsaroundthebindingsiteofC1sandreactswithbothactiveandinactiveC1s.Specifications:CatalognumberHM2108-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mg(100µ/ml)0.2µmfilteredantibodysolutioninPBS-(exactconcentrationisindicatedonthelabel)ApplicationFlowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunoprecipitation,Paraffinsections,WesternblotUseForimmunohistology,flowcytometryandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10.ForinhibitionofC4activationbyC1sdilutionshavetobemadeaccordingtotheamountsC1stobeinactivated.IsotypeMouseIgG1SpeciesHumanReferences1.Matsumoto,Metal;ProbingtheC4-bindingsiteonC1swithmonoclonalantibodies,evidenceforaC4/C4b-bindingsiteonthegamma-domain.JImmunol1989,8:27432.Nakagawa,Ketal;ComplementC1sactivationindegeneratingarticularcartilageofrheumatoidarthritispatients:immunohistochemicalstudieswithanactiveformspecificantibody.AnnRheumDis1999,58:175StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。