首页 > Hycult Biotech > Hycult Biotech/LOX-1, Human, mAb 23C11, functional study antibody, low endotoxin/HM2138-FS/0.5 mg

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Hycult Biotech/LOX-1, Human, mAb 23C11, functional study antibody, low endotoxin/HM2138-FS/0.5 mg

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HM2138-FS

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Description:LOX-1,Human,mAb23C11,functionalstudyantibody,lowendotoxinThemonoclonalantibody23C11recognizesoxidizedlow-densitylipoproteinreceptor-1(LOX-1).LOX-1isasingle-passtypeIImembraneprotein(~45kDa)andbelongstotheC-typelectin-likeproteinsuperfamily.LOX-1isexpressedathighlevelinendothelialcellsandvascular-richorganssuchasplacenta,lung,liver,brainaorticintima,bonemarrow,spinalcordandsubstantianigra.Itisalsoexpressedonthesurfaceofdendriticcells.ThisuniquescavengerreceptorLOX-1playsimportantrolesinatherogenesis.LOX-1mediatestherecognition,internalizationanddegradationofoxidativelymodifiedlowdensitylipoprotein(oxLDL)byvascularendothelialcells.OxLDLisaMarkerofatherosclerosis,inducingvascularendothelialcellactivationanddysfunction,resultinginpro-inflammatoryresponses,pro-oxidativeconditionsandapoptosis.LOX-1associateswithoxLDLinducingtheactivationofNF-kappa-Bthroughanincreasedproductionofintracellularreactiveoxygenandavarietyofpro-atherogeniccellularresponsesincludingareductionofnitricoxide(NO)release,monocyteadhesionandapoptosis.InadditiontobindingoxLDL,LOX-1actsasareceptorfortheHSP70proteininvolvedinantigencross-presentationtonaiveT-cellsindendriticcells,therebyparticipatingincell-mediatedantigencross-presentation.LOX-1isinvolvedintheinflammatoryprocess,byactingasaleukocyte-adhesionmoleculeatthevascularinterfaceinendotoxin-inducedinflammation.LOX-1alsoactsasareceptorforadvancedglycationend(AGE)products,activatedplatelets,monocytes,apoptoticcellsandbothGram-negativeandGram-positivebacteria.TheLOX-1geneisaso-calledimmediateearlygenethatisdynamicallymodulatedbyseveralfactorsinvitroandinvivo.LOX-1expressionisinducedbystimulisuchasinflammatorycytokines,OxLDL,TNF-alpha,TGF-beta,andANGIIinvitro,andseveralproatherogenicfactorsinvivo.Monoclonalantibody23C11neutralizesLOX-1andinhibitsHsp70bindingtodendriticcellsandHsp70-inducedantigencross-presentation.Invivo,targetingLOX-1withatumorantigenusinganti-LOX-1antibody23C11inducesanti-tumorimmunity.Specifications:CatalognumberHM2138-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mg(100µg/ml)0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel)ApplicationFlowcytometry,Functionalstudies,Immunofluorescence,ParaffinsectionsApplicationNotesFC:10 µg/mlantibodyusedonhumanperipheralbloodmyeloidDCandmacrophagesFS:antibodytotallypreventedHsp70bindingtoLOX-1-CHObutnotmock-transfectedCHOcells(Ref1)UseForflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsettting.ImmunogenFusionproteinofextracellulardomain(aa71-273)ofhumanLOX-1withmurineFcγ1(LOX-1-muFc)producedinPEAKcellsIsotypeMouseIgG1SpeciesHumanCrossreactivityMouse-YesAliasLectin-likeoxidizedLDLreceptor1,Ox-LDLreceptor1,C-typelectindomainfamily8memberAPositiveControlHumanAPCsReferences1.Delneste,Yetal;InvolvementofLOX-1indendriticcell-mediatedantigencross-presentation.Immunity2002,17:3532.Jeannin,Petal;ComplexityandcomplementarityofoutermembraneproteinArecognitionbycellularandhumoralinnateimmunityreceptors.Immunity2005,22:5513.Parlato,Setal;LOX-1asanaturalIFN-;-mediatedsignalforapoptoticcelluptakeandantigenpresentationinedndriticcells.Blood2010,115:1554StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseCardiologyandmetabolism

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。