首页 > Hycult Biotech > Hycult Biotech/TNF-alpha, Human, mAb 5N, functional study antibody, low endotoxin/HM2218-FS/0.5 mg

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Hycult Biotech/TNF-alpha, Human, mAb 5N, functional study antibody, low endotoxin/HM2218-FS/0.5 mg

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HM2218-FS

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Description:TNF-alpha,Human,mAb5N,functionalstudyantibody,lowendotoxinThemonoclonalantibody5NreactswithTumorNecrosisFactoralpha(TNF-alpha).Tumornecrosisfactor-alpha(TNF-alpha),ahomotrimeric17KDprotein,isapotentmediatorofinflammatoryandmetabolicfunctions.TNF-alphawasoriginallydetectedasahighlycytotoxiccytokinefortumorcells,itcausestumornecrosisinvivoandshowscytolyticactivityagainsttumorcellsinvitro.FurtherTNF-alphahasbeenimpliedascentralmediatorinshockinducedbygramnegativemicro-organisms.ThecytokineTNF-alphaisfoundtobeacentralmediatorinmanyinflammatoryandimmunologicalprocesses:itcanbeinducedbyvariousproductsofmicro-organismsandbyvariouscytokinesbutitalsoinducesonitsturntheproductionofmanycytokines.SignaltransductionoccursviatwotypesofTNF-receptors,theTNF-receptorsIandII.Thereceptorsdifferstronglyintheirintra-cellularsignalingpathways.TheTNF-alphatrimerinteractswitheitherofthetwotypesofTNF-RleADIngtoreceptorcross-linking.Themonoclonalantibody5Ncross-reactsandcross-neutralizesallmonkeyspeciesTNF-alpha,exceptpig-tailmacaque.WithaffinityabouttwoordersloweritrecognizesbovineandcanineTNF-alpha.Specifications:CatalognumberHM2218-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mg(500µg/ml)0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel)ApplicationFunctionalstudies,ImmunoassaysUseForneutralizationofBIOLOGicalactivityinvitrodilutionshavetobemadeaccordingtotheamountsofTNF-alphatobeinactivated.Theaffinityofthemonoclonalantibody5Nis5.7x10-10M.ThehomologousELISAisusefulforthedetectionofoligomerichumanTNF-alpha.ItdoesnotrecognizemonomericTNF-alpha.IsotypeMouseIgG2aSpeciesHumanCrossreactivityBovine-Yes,Canine-Yes,Monkey-YesAliasTNF,TNF-SF2,DIF,CachectinReferences1.Petyovka,Netal;HomologousELISAfordetectionofoligomerichumanTNF:propertiesoftheassay.JImmunolMethods1995,186:1612.Song,Xetal;Effectsof2differentanti-tumornecrosisfactor-alphaagentsinaprimatemodelofsubcutaneousformation.JInfectDis2002,185:204StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseAutoimmunity,Gastroenterology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。