首页 > Hycult Biotech > Hycult Biotech/PTX3, Human, mAb MNB1, functional study antibody, low endotoxin/HM2241-FS/0.5 mg

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Hycult Biotech/PTX3, Human, mAb MNB1, functional study antibody, low endotoxin/HM2241-FS/0.5 mg

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Description:PTX3,Human,mAbMNB1,functionalstudyantibody,lowendotoxinThemonoclonalantibodyMNB1(previouslyknownasclone16B5)recognizeshumanpentraxin3(PTX3),belongingtothelongpentraxinfamily.PTX3isanacute-phaseglycoproteinof~45kDawithglycosylationaccountingforabout10%ofitsmolecularweight.PTX3hasacomplexoligomericstructurewithprotomerslinkedtoeachotherbydisulfidebonds.PTX3expressionistriggeredbyinflammatorycytokines,resultinginhigherlevelsofcirculatingPTX3.SeveralcelltypeshavebeenreportedtoproducePTX3,namelymacrophages,endothelialcells,neutrophilsandsynoviocytes.PTX3isinvolvedinhostdefenseagainstpathogeninfection,intheregulationofthescavengeractivityofmacrophagesanddendriticcells,andinmodulationofcomplementactivitybybindingtoC1q.FurThermore,PTX3hasbeenimplicatedinmatrixdepositionofcumuluscells.Moreover,PTX3interactswithotherBIOLOGicallyactivemolecules,causingtheirfunctionalblockade.Thishasbeendemonstratedforfibroblastgrowthfactor-2(FGF-2),forwhichPTX3actsasaninhibitor,leADIngtoinhibitionofangiogenesis.PTX3,likeotherpentraxinsC-reactiveprotein(CRP)andserumamyloidPcomponent(SAP),bindsapoptoticcellsanddebris.PTX3isusefulasanearlyindicatorofmyocyteirreversIBLeinjuryinischemiccardiomyopathy.PTX3isnotonlyinvolvedininflammatoryvesseldiseasesrelatedtoatherosclerosis,butalsoinpre-eclampsiaandsystemicsmallvesselANCA-associatedvasulitis,inwhichneutrophilsarekeyplayers.Therelationshipbetweentissuedamageandpentraxingenerationisstringentinacuteinjuries.PTX3tunesself-non-selfdiscriminationandtissuerepairduetotherecognitionofdiverseligandsbyPTX3andthroughregulationofeffectorpathways.Specifications:CatalognumberHM2241-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFlowcytometry,Functionalstudies,Immunoassays,WesternblotApplicationNotesIA:theantibodycanbeusedasdetectionantibody.W:Reducedsampletreatment.Theexpectedbandsizesareapproximately42and90kDa.UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenHumanrecombinantPTX3IsotypeRatIgG2bSpeciesHumanAliasPTX3,Pentraxin-relatedproteinPTX3,Tumornecrosisfactor-induciblegene14protein,TSG-14Genename:PTX3,TNFAIP5,TSG14References1.Bottazzi,Betal;MultimerFormationandLigandRecognitionbytheLongPentraxinPTX3.JBC1997,272:328172.Camozzi,Metal;IdentificationofanAntiangiogenicFGF2-bindingSiteintheNTerminusoftheSolublePatternRecognitionReceptorPTX3*.JBC2006,281:226053.Jaillon,Setal;ThehumoralpatternrecognitionreceptorPTX3isstoredinneutrophilgranulesandlocalizesinextracellulartraps.JExpMed2007,204:7934.Jaillon,Setal.EndogenousPTX3translocatesatthemembraneoflateapoptotichumanneutrophilsandisinvolvedintheirengulfmentbymacrophages.CellDeathDiff2009,16:465-4745.Hamon,Yetal,ProteolyticcleavageofthelongpentraxinPTX3intheairwaysofcysticfibrosispatients.InnImm2013,19:611StorageandstABIlityProductshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseCardiologyandmetabolism,Infectiousdiseases

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