首页 > Hycult Biotech > Hycult Biotech/TLR4/MD-2, Human, mAb 7E3, functional study antibody, low endotoxin/HM2246-FS/0.5 mg

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Hycult Biotech/TLR4/MD-2, Human, mAb 7E3, functional study antibody, low endotoxin/HM2246-FS/0.5 mg

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HM2246-FS

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Description:TLR4/MD-2,Human,mAb7E3,functionalstudyantibody,lowendotoxinThemonoclonalantibody7E3reactswiththeToll-likereceptor4(TLR4,CD284)/MD-2complex.TLRsbelongtoafamilyofproteinsthatspecificallyrecognizesandsensesmicrobialproducts.Theyarehighlyconservedthroughoutevolutionandactasinnateimmunerecognitionreceptorsagainstmanypathogens.TLR4isafunctionalreceptorforgram-negativebacteriallipopolysaccharides(LPS).TLR4associateswithMD-2whichisabsolutelyrequiredforLPS-inducedactivationofTLR4.MD-2existsasacellsurfaceproteininassociationwithTLR4.ItalsoexistsassecretedformsconsistingofMD-2monomersandmultimers(sMD-2).CirculatingsMD-2ismainlypresentasadoubletof~20and25kD,representingdifferentiallyglycosylatedforms.UnlikeTLR4,sMD-2bindsdirectlyLPSwithouttheneedofsolubleCD14(sCD14).However,LPS-MD-2interactionsareincreasedwhenLPSispretreatedwithCD14.OnlymonomericsMD-2isBIOLOGicallyactiveandabletoassociatewithTLR4andLPS.sMD-2circulatesinplasmaofhealthyindividualsasanon-active,polymericprotein.Insepticplasma,thetotalamountofsMD-2wasstronglyelevatedandcontainedbothsMD-2polymersandmonomers.SolubleMD-2isproposedtobeanimportantmediatoroforganinflammationduringsepsis.Duringexperimentalhumanendotoxemia,themonomericandtotalsMD-2contentinplasmaincreasedwiththekineticsofanacutephaseprotein.ThisparallelsenhancedTLR4costimulatoryactivity.InvitrostudiesrevealedthatsMD-2releaseappearstoberestrictedtoendothelialanddendriticcells.Themonoclonalantibody7E3reactswiththeTLR4/MD-2complexandisabletoinhibitthebiologicalactivityoftheTLR4/MD-2complex.Specifications:CatalognumberHM2246-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mg(100µg/ml)0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel)ApplicationFlowcytometry,FunctionalstudiesUseForflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ForfunctionalstudiesdilutionshavetobemadeaccordingtotheamountsofMD-2tobeinactivated.ImmunogenTLR4/MD-2expressingCHOcells/chimericTLR4/MD-2fusionproteinIsotypeMouseIgG1SpeciesHumanAliasCD284/Lymphocyteantigen96,ESOP-1,LY96StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseInfectiousdiseases

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。