首页 > Hycult Biotech > Hycult Biotech/C3b/iC3b, Human, mAb 5G9, functional study antibody, low endotoxin/HM2285-FS/0.5 mg

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Hycult Biotech/C3b/iC3b, Human, mAb 5G9, functional study antibody, low endotoxin/HM2285-FS/0.5 mg

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HM2285-FS

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Description:C3b/iC3b,Human,mAb5G9,functionalstudyantibody,lowendotoxinThemonoclonalantibody5G9recognizesComplementFactorC3b/iC3b,itspecificallybindshumanC3aswellasthebreakdownproductsC3bandiC3b.C3playsacentralroleintheactivationofthecomplementsystem.Itsactivationisrequiredforbothclassicalandalternativecomplementactivationpathways.PeoplewithC3deficiencyaresusceptIBLetobacterialinfection.OneformofC3-convertase,alsoknownasC4b2a,isformedbyaheterodimerofactivatedformsofC4andC2.ItcatalyzestheproteolyticcleavageofC3intoC3aandC3b,generatedduringactivationthroughtheclassicalpathwayaswellasthelectinpathway.C3aisananaphylotoxinandtheprecursorofsomecytokinessuchasASP,andC3bservesasanopsonizingagent.FactorIcancleaveC3bintoC3candC3d,thelatterofwhichplaysaroleinenhancingBcellresponses.Inthealternativecomplementpathway,C3iscleavedbyC3bBb,anotherformofC3-convertasecomposedofactivatedformsofC3(C3b)andfactorB(Bb).OnceC3isactivatedtoC3b,itexposesareactivethioesterthatallowsthepeptidetocovalentlyattachtoanysurfacethatcanprovideanucleophilesuchasaprimaryamineorahydroxylgroup.ActivatedC3cantheninteractwithfactorB.FactorBisthenactivatedbyfactorD,toformBb.Theresultantcomplex,C3bBb,iscalledthealternativepathway(AP)C3convertase.C3bBbisdeactivatedinsteps.First,theproteolyticcomponentoftheconvertase,Bb,isremovedbycomplementregulatoryproteinshavingdecay-acceleratingfactor(DAF)activity.Next,C3bisbrokendownprogressivelytofirstiC3b,thenC3c+C3dg,andthenfinallyC3d.FactorIistheproteasethatperformsthesecutswithCR1ascofactor.Clone5G9recognizeseparate,non-overlappingepitopesonC3fragments.LevelsofC3inthebloodmaybemeasuredtosupportorrefuteaparticularmedicaldiagnosis.Forexample,lowC3levelsareassociatedwithsometypesofkidneydiseasesuchaspost-infectiousglomerulonephritisandshuntnephritis.Specifications:CatalognumberHM2285-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFunctionalstudiesApplicationNotesmAb5G9inhibitstheclassicalpathwayandnotthealternativepathway(Ref1).UseThetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting.IsotypeMouseIgG2aSpeciesHumanReferences1.Lindorfer,Metal;Anovelapproachtopreventingthehemolysisofparoxysmalnocturnalhemoglobinuria:bothcomplement-mediatedcytolysisandC3depositionareblockedbyamonoclonalantibodyspecificforthealternativepathwayofcomplement.Blood2010,115:11StorageandstABIlityProductshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。