首页 > Hycult Biotech > Hycult Biotech/TNF-RII, Human, mAb 80M2, functional study antibody, low endotoxin/HM2022-FS/0.5 mg

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Hycult Biotech/TNF-RII, Human, mAb 80M2, functional study antibody, low endotoxin/HM2022-FS/0.5 mg

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HM2022-FS

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Description:TNF-RII,Human,mAb80M2,functionalstudyantibody,lowendotoxinThemonoclonalantibody80M2recognizestheextracellularpartof-membrane-boundTNF-RIIaswellas-thesolubleformofTNF-RIIwhichisgeneratedbyproteolyticcleavageoftheextracellulardomain.ThesolubleformcanstillbindTNF-alphawithhighaffinityandfunctionsasaTNF-alphaantagoNIST.-TNF-alphaisanimportantsignalingproteinintheimmunesystemwhichcanactivateinflammatoryresponses,induceapoptosis,regulatecellularproliferation,andmayevenpromotecancerprogression.TNF-alphacanbindtotwostructurallydistinctmembranereceptors,TNF-RIandTNF-RII,whichhavebothdistinctandoverlappingdownstreamsignalingcascades.TNFRIisbelievedtobeexpressedonnearlyallcelltypes,whereasTNFRIIexhibitsmorerestrictedexpression,beingfoundoncertainsubpopulationsofimmunecellsandseveralothercelltypes.AdominantroleofTNF-RIIhasbeenshowninthymocyteactivationbyTNF-alpha,whereasinductionofcytotoxicityandotherfunctionsaremediatedlargelybyTNF-RI.TNF-RIisequallywellactivatedbyboththe17kDasolubleand26kDamembrane-boundform,whereasTNF-RIIisactivatedonlybythemembraneboundformofTNF-alpha.Theantibodyisanon-agonisticreceptormodulatingantibody.ItenhancesinvitroTNFalpharesponsesbyincreasingtheaffinityofthesolubleformofTNF-alphaforTNF-RII.Specifications:CatalognumberHM2022-FSProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mg(100µg/ml)0.2 µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel)ApplicationFlowcytometry,Functionalstudies,Immunoassays,Immunofluorescence,ImmunoprecipitationApplicationNotesFC:Antibody80M2wasusedtoselectHeLacellsexpressingTNF-RII-by-FACS.AsnegativecontrolmocktransfectedHeLacellswereused.(Ref.2)FS:Antibody80M2functionsasanallostericmodulator,whichstABIlizestheligand-receptorcomplex.(Ref.1)UseForimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting.IsotypeMouseIgG1SpeciesHumanCrossreactivityRat-YesAliasTumornecrosisfactorreceptorsuperfamilymember1B,CD120b,TNF-R2,p75,p80TNF-alphareceptorPositiveControlHeLacells-transfectedwithTNF-RIIReferences1.Grell,Metal;Thetransmembraneformoftumornecrosisfactoristheprimeactivatingligandofthe80kDatumornecrosisfactorreceptor.Cell1995,83:7932.Till,Aetal;TheMet196-Argvariationofhumantumornecrosisfactorreceptor2(TNFR2)affectsTNF-alphainducedapoptosisbyimpairedNF-kBsignallingandtargetgeneexpression.JBiolChem2005,280:59943.ScherublC.etal;ColocalizationofendogenousTNFwithafunctionalintracellularspliceformofhumanTNFreceptortype2.JournalofInflammation2005,2:74.Krippner,Aetal;SinglechainTNF,aTNFderivativewithenhancedstabilityandantitumoralactivity.JImmunol2008,180:81765.Fairfax,Betal;AcommonhaplotypeoftheTNFreceptor2genemodulatesendotoxintolerance.J.Immonol2011,186:3058StorageandstabilityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseAutoimmunity,Gastroenterology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。