首页 > Hycult Biotech > Hycult Biotech/S100A9, Mouse, mAb MU14-2A5, immuno assay antibody/HM1102-IA/0.5 mg

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Hycult Biotech/S100A9, Mouse, mAb MU14-2A5, immuno assay antibody/HM1102-IA/0.5 mg

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HM1102-IA

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Description:S100A9,Mouse,mAbMU14-2A5,immunoassayantibodyThemonoclonalantibodyMU14-2A5recognizesS100A9.Thecalcium-binding,migrationinhibitoryfactor-relatedproteins,MRP-8(S100A8)andMRP-14(S100A9)belongtotheS100proteinfamily.MRP14isco-expressedwithhumanMRP8,ahomologueproteininmyeloidcells,andplaysanessentialroleincalciumdependentfunctionsduringinflammation.ThisroleincludestheactivationofMac-1,theβ2integrinwhichisinvolvedinneutrophiladhesiontoendothelialcells.MRP14isdistinguishedfromotherS100memberproteinsbyitslongC-terminalregion.TheexpressionofMRP-8(S100A8)andMRP-14(S100A9)islargelyconfinedtothecytosolofneutrophilsandmonocytes.Thecomplexformationoftheseproteinsisacalcium-dependentprocess.TheS100A8/A9heterocomplex,alsocalledMRP-8/MRP-14complexorcalprotectin,comprises60%ofthecytoplasmicproteinfractionofcirculatingpolymorphonucleargranulocytesandisalsofoundinmonocytes,macrophagesandilealtissueeosinophils.Ininflammatoryconditionssmallvenuelesstainwithbothanti-S100A8andS100A9.Thestainingofthetwosubunitsisalwayscoincident.TheS100A8/A9complexhasantibacterial,antifungalandimmunomodulatingandantiproliferativeeffects.Besidesthisitisapotentchemotacticfactorforneutrophils.Specifications:CatalognumberHM1102-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFrozensections,Functionalstudies,Immunoassays,Immunofluorescence,Paraffinsections,WesternblotApplicationNotesW:AreducedsampletreatmentandSDS-Pagewasused.Thebandsizeis13-15kDa.UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenCompletemouseS100A9proteinIsotypeMouseIgG1SpeciesMouseCrossreactivityRabbit-NoAliasMigrationinhibitoryfactor-relatedprotein14,MRP14,CalgranulinBGenename:S100a9,Cagb,Mrp14PositiveControlMousebonemarrowcellextractsStorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseGastroenterology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。