首页 > Hycult Biotech > Hycult Biotech/MASP-2, Human, mAb 8B5, immuno assay antibody/HM2190-IA/0.5 mg

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Hycult Biotech/MASP-2, Human, mAb 8B5, immuno assay antibody/HM2190-IA/0.5 mg

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HM2190-IA

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Description:MASP-2,Human,mAb8B5,immunoassayantibodyThemonoclonalantibody8B5reactswiththeCCP1/2-SPfragmentofhumanMASP-2.MASP-2isatrypsin-likeserineproteaseandplaysanimportantrolintheinitiationoftheMBLcomplementactivationpathway.Threepathwaysofcomplementactivationhavebeenreported:theantibody-dependentclassicalpathway,theantibody-independentalternativepathwayandthelectinpathway.Activationofeachpathwayinvolvesformationofserineproteasecomplexes,whichresultsinactivationofthecentralcomplementcomponentC3.Inthelectinpathway,mannosebinding-lectin(MBL)-associatedserineproteases(MASPs)formcomplexeswithpolymericlectinmoleculeswhichareinvolvedinpatternrecognition.Uponbindingoftherecognitionmoleculestocarbohydratesonthesurfaceofmicroorganisms,MASPsareconvertedtotheiractiveformsandinitiatecomplementactivation.ThreetypesofhumanMASPhavebeenreported.MASP-1,MASP-2andMASP-3.Mannan-bindinglectin(MBL)andficolins,incomplexwithMBL-associatedserinproteases(MASPs),arecapableofactivationthecomplementsystem,thusmediatingthedestructionofinfectiousagents.MASP-2cleavesC4andC2andiscrucialfortheactivationofdownstreamcomplementcomponents.Specifications:CatalognumberHM2190-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationImmunoassays,WesternblotUseForWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10.IsotypeRatIgG1SpeciesHumanReferencesMoller-Kristensen,Metal;Levelsofmannan-bindinglectin-associatedserineprotease-2inhealthyindividuals.JImmunol2003,282:159StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseInfectiousdiseases

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。