首页 > Hycult Biotech > Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12, immuno assay antibody/HM2191-IA/0.5 mg

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Hycult Biotech/MASP-2/MAp19, Human, mAb 6G12, immuno assay antibody/HM2191-IA/0.5 mg

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HM2191-IA

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Description:MASP-2/MAp19,Human,mAb6G12,immunoassayantibodyThemonoclonalantibody6G12reactswithhumanMASP-2andhumanMAp19.MASP-2isatrypsin-likeserineproteaseandplaysanimportantroleintheinitiationoftheMBLcomplementactivationpathway.Threepathwaysofcomplementactivationhavebeenreported:theantibody-dependentclassicalpathway,theantibody-independentalternativepathwayandthelectinpathway.Activationofeachpathwayinvolvesformationofserineproteasecomplexes,whichresultsinactivationofthecentralcomplementcomponentC3.Inthelectinpathway,mannosebinding-lectin(MBL)-associatedserineproteases(MASPs)formcomplexeswithpolymericlectinmoleculeswhichareinvolvedinpatternrecognition.Uponbindingoftherecognitionmoleculestocarbohydratesonthesurfaceofmicroorganisms,MASPsareconvertedtotheiractiveformsandinitiatecomplementactivation.ThreetypesofhumanMASPhavebeenreported.MASP-1,MASP-2andMASP-3.Mannan-bindinglectin(MBL)andficolins,incomplexwithMBL-associatedserinproteases(MASPs),arecapableofactivationthecomplementsystem,thusmediatingthedestructionofinfectiousagents.MASP-2cleavesC4andC2andiscrucialfortheactivationofdownstreamcomplementcomponents.MAp19isanalternativesplicingproductoftheMASP-2gene.MAp19comprisesthefirsttwodomainsofMASP-2followedbyanextrasequenceoffouruniqueaminoacids(EQSL)atitsC-terminal.MASP-2andMAp19havebeenreportedtobindtoMBLinacalcium-dependentmanner.Themonoclonalantibody6G12reactswithhighaffinitytotheN-terminalendofMASP-2andMap19.Specifications:CatalognumberHM2191-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationImmunoassays,WesternblotApplicationNotesIA:theantibodycanbeusedasdetectionantibody.W:Bothreducedandnon-reducedcanbeperformed.TheexpectedbandsizeforMASP-2isapproximately75kDaandforMap19approximately20kDa.UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenrMAp19(Ref.1)IsotypeRatIgG1SpeciesHumanReferences1.Moller-Kristensen,Metal;Levelsofmannan-bindinglectin-associatedserineprotease-2inhealthyindividuals.JImmunol2003,282:1592.Krarup,Aetal;L-ficolinIsaPatternRecognitionMoleculeSpecificforAcetylGroups*.JBC2004,46:475133.Ameye,Letal;M-ficolinlevelsareassociatedwiththeoccurrenceofsevereinfectionsinpatientswithhaematologicalcancerundergoingchemotherapy.ClinExpImm2011,167:3034.Zacho,Retal;StudiesofthePatternRecognitionMoleculeH-ficolin.JBC2012,11:80715.DamgaardSandahl,Tetal;ThelectinpathwayofthecomplementsystemisdownregulatedinCrohn"sdiseasepatientswhorespondtoanti-TNF-αtherapy.JCrohnCol2013,8:5216.Man-Kupisinska,Aetal;ANewLigand-BasedMethodforPurifyingActiveHumanPlasma-DerivedFicolin-3ComplexesSupportsthePhenomenonofCrosstalkbetweenPattern-RecognitionMoleculesandImmunoglobulins.PLoSONE2016,11:e0156691StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseInfectiousdiseases

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。