首页 > Hycult Biotech > Hycult Biotech/C3d, Human, mAb 3, immuno assay antibody/HM2198-IA/0.5 mg

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Hycult Biotech/C3d, Human, mAb 3, immuno assay antibody/HM2198-IA/0.5 mg

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HM2198-IA

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Description:C3d,Human,mAb3,immunoassayantibodyThemonocolonalantibody3(alsoknownasYB2/39-11-1-7)reactswithalineardeterminantinC3d.This"D"antigenisfoundonC3,C3b,iC3b,C3dgandC3d.Thecomplementsystemisanimportantfactorininnateimmunity.Thethirdcomplementcomponent,C3,iscentraltotheclassical,alternativeandlectinpathwaysofcomplementactivation.Activationproductsofthecomplementcascadecontainneo-epitopesthatarenotpresentintheindividualnativecomponents.ThesynthesisofC3istissue-specificandismodulatedinresponsetoavarietyofstimulatoryagents.C3isthemostabundantproteinofthecomplementsystemwithserumproteinlevelsofabout1.3mg/ml.AninheriteddeficiencyofC3predisposesthepersontofrequentbacterialinfections.C3fragmentsaredepositedintissuesatsitesofantibody-mediatedimmunopathology.Inulcerativecolitisandidiopathicchronicinflammatoryboweldisease,thedepositionofC3inthediseasedmucosahasbeenreported.ProteolysisbyC3-convertasesresultsinthecleavageofC3intoC3aandC3b.C3bbecomesattachedtoimmunecomplexesandisfurthercleavedintoiC3bandC3f.iC3bisfurtherprocessedintoC3candC3dg.C3dgcanbecleavedintoC3dandC3g,thoughthisdoesnotoccurinplasma.Themonoclonalantibody3recognizesC3,C3b,iC3b,C3dgandC3d.ThemonoclonalantibodydoesnotrecognizeC3c.TodistinguishC3fromC3bananti-C3aantibodyisnecessary(HM2074).Specifications:CatalognumberHM2198-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel),containing0.02%sodiumazide.ApplicationImmunoassays,ImmunoprecipitationIsotypeRatIgG2aSpeciesHumanReferences1.Lachmann,Petal;ThreemonoclonalantibodiestohumanC3.Immunology1980,41:5032.Lachmann,Petal;BreakdownofC3aftercomplementactivation.IdentificationofanewfragmentC3g,usingmonoclonalantibodies.JExpMed1982,156:2053.Lachmann,Petal;Useofmonoclonalanti-C3antibodiestocharacterisethefragmentsofC3thatarefoundonerythrocytes.VoxSang1983,45:3674.Chaplin,Hetal;FurtherstudiesoftheC3gcomponentofthealpha2DfragmentofhumanC3.ClinExpImmunol1983,51:639StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。