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Hycult Biotech/Defensin 5, Human, mAb 8C8, immuno assay antibody/HM2228-IA/0.5 mg
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Description:Defensin5,Human,mAb8C8,immunoassayantibodyThemonoclonalantibody8C8recognizeshumanalpha-defensin5(HD5).HD5isanantimicrobialpeptideproducedbyPanethcells,specializedepithelialcellsofthesmallintestinalcrypt.HD5isstoredinthePanethcellsaspropeptide(aa20-94)andreleasedasmaturepeptideaftertrypsindigestion,whichisco-secretedfromthePanethcellgranules.ThematureHD5(aa63-94)isprotectedfromfurtherdigestionbytheproteolysisenzyme.HD5functionsinmaintainingthecorrectmicrobialbalanceintheintestine.TransgenicmicethatexpressHD5areprotectedfromlethalchallengecausedbySalmonellatyphimurium.ExpressionlevelsofHD5arenegativelycorrelatedtointestinalinfection.HD5isausefulMarkerforintestinalmetaplasiaoftheuppergastrointestinaltract.HD5expressionhasalsobeendetectedintheupperhalfofthestratifiedsquamousepitheliumofthevaginaandectocervixwithincreasingintensitytowardthelumen.SecretedHD5isdetectableincervicovaginallavages,withhighestconcentrationsduringthesecretoryphaseofthemenstrualcycle.Themonoclonalantibody8C8wasraisedagainstrecombinantHD5(aa20-94)andrecognizesthepropeptideandthepartiallyprocessedforms(aa36-94and56-94),butithardlyrecognizesmaturepeptide.NocrossreactivitywithHD6,lysozyme,orsPLA2couldbedetected.Specifications:CatalognumberHM2228-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFrozensections,Immunoassays,WesternblotUseForimmunohistologyandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.IsotypeMouseIgG2bSpeciesHumanAliasDEFA5References1.Kelly,Petal;Reducedgeneexpressionofintestinalalpha-defensinspredictsdiarrheainacohortofAfricanadults.JInfDis2006,193:14642.Shen,Betal;Humandefensin5expressioninintestinalmetaplasiaoftheuppergastrointestinaltract.JClinPathol2005,58:6873.Kelly,Petal;Panethcellgranuledepletioninthehumansmallintestineunderinfectiveandnutritionalstress.ClinExpImmunol2004,135:303StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseGastroenterology,Infectiousdiseases

荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。

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