首页 > Hycult Biotech > Hycult Biotech/PTX3, Human, mAb MNB4, immuno assay antibody/HM2242-IA/0.5 mg

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Hycult Biotech/PTX3, Human, mAb MNB4, immuno assay antibody/HM2242-IA/0.5 mg

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HM2242-IA

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Description:PTX3,Human,mAbMNB4,immunoassayantibodyThemonoclonalantibodyMNB4(previouslyknownasclone20)recognizeshumanpentraxin3(PTX3),belongingtothelongpentraxinfamily.PTX3isanacute-phaseglycoproteinof~45kDawithglycosylationaccountingforabout10%ofitsmolecularweight.PTX3hasacomplexoligomericstructurewithprotomerslinkedtoeachotherbydisulfidebonds.PTX3expressionistriggeredbyinflammatorycytokines,resultinginhigherlevelsofcirculatingPTX3.SeveralcelltypeshavebeenreportedtoproducePTX3,namelymacrophages,endothelialcells,neutrophilsandsynoviocytes.PTX3isinvolvedinhostdefenseagainstpathogeninfection,intheregulationofthescavengeractivityofmacrophagesanddendriticcells,andinmodulationofcomplementactivitybybindingtoC1q.FurThermore,PTX3hasbeenimplicatedinmatrixdepositionofcumuluscells.Moreover,PTX3interactswithotherBIOLOGicallyactivemolecules,causingtheirfunctionalblockade.Thishasbeendemonstratedforfibroblastgrowthfactor-2(FGF-2),forwhichPTX3actsasaninhibitor,leADIngtoinhibitionofangiogenesis.PTX3,likeotherpentraxinsC-reactiveprotein(CRP)andserumamyloidPcomponent(SAP),bindsapoptoticcellsanddebris.PTX3isusefulasanearlyindicatorofmyocyteirreversIBLeinjuryinischemiccardiomyopathy.PTX3isnotonlyinvolvedininflammatoryvesseldiseasesrelatedtoatherosclerosis,butalsoinpre-eclampsiaandsystemicsmallvesselANCA-associatedvasulitis,inwhichneutrophilsarekeyplayers.Therelationshipbetweentissuedamageandpentraxingenerationisstringentinacuteinjuries.PTX3tunesself-non-selfdiscriminationandtissuerepairduetotherecognitionofdiverseligandsbyPTX3andthroughregulationofeffectorpathways.Specifications:CatalognumberHM2242-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFlowcytometry,Frozensections,Immunoassays,Immunofluorescence,Immunoprecipitation,Paraffinsections,WesternblotUseForimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50..ImmunogenHumanrecombinantPTX3IsotypeRatIgG2aSpeciesHumanAliasPentraxin-relatedproteinPTX3,Tumornecrosisfactor-induciblegene14protein,TSG-14References1.Peri,Getal;PTX3,aprototypicallongpentraxin,isanearlyindicatorofacutemyocardialinfarctioninhumans.Circulation2000,102:6362.Fazzini,Fetal;PTX3insmall-vesselvasculitides:anindependentindicatorofdiseaseactivityproducedatsitesofinflammation.ArthritisRheum2001,44:28413.Bussolati,Betal;ThelongpentraxinPtx3issynthesizedinIgAglomerulonephritisandactivatesmesangialcells.Jimmunol2003,170:14664.Inforzato,Aetal;StructureandfunctionofthelongpentraxinPTX3glycosidicmoiety:fine-tuningoftheinteractionwithC1qandcomplementactivation.Biochemistry2006,45:115405.Jaillon,Setal;ThehumoralpatternrecognitionreceptorPTX3isstoredinneutrophilgranulesandlocalizesinextracellulartraps.JExpMed2007,204:793StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseCardiologyandmetabolism,Infectiousdiseases

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