首页 > Hycult Biotech > Hycult Biotech/C9 neoantigen, Human, mAb WU13-15, immuno assay antibody/HM2264-IA/0.5 mg

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Hycult Biotech/C9 neoantigen, Human, mAb WU13-15, immuno assay antibody/HM2264-IA/0.5 mg

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HM2264-IA

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Description:C9neoantigen,Human,mAbWU13-15,immunoassayantibodyThemonoclonalantibodyWU13-15recognizesaneoepitopeonthe61kDacomplementcomponentC9,integratedintheterminalcomplementcomplex(TCC).Thecomplementsystemisanancientproinflammatoryandmicrobialdestructionsystem,thatmaybeconsideredpartofboththeinnateandadaptiveimmunesystems.Itconsistsoftheclassical,alternative,andlectin-bindingpathways.Eachpathwayistriggeredinadistinctmanner,yetalldepositC3fragmentsonatargetandengageacommonterminalsequencecalledTCCorthe"membraneattackcomplex"(MAC).Incontrasttotheactivationpathways,whichrequireenzymaticcleavageforactivation,theterminalpathwayreliesonconformationalchangesinducedbybindingofthedifferentsubunits.TCCiscomposedofacomplexoffourcomplementproteins(C5b,C6,C7,andC8)whichbindtotheoutersurfaceofthetargetplasmamembrane,andmanycopiesofafifthprotein(C9)thathookuptooneanother,formingaringinthemembrane.TheringstructureformedbyC9isaporeinthemembranethatallowsfreediffusionofmoleculesinandoutofthecell.Ifenoughporesform,thecellisnolongerabletosurvive.Themembraneattackcomplexisinitiatedwhenthecomplementprotein,C5convertase,cleavesC5intoC5aandC5b.BindingofC6facilitatesbindingofC7whichalterstheconformationofthecomplex.AfterbindingofC8,avariablenumberofC9moleculesassociatewiththeC5b678complex,togetherconstitutingTCC.TheformationofTCCcauseslysisofcellsorcantriggeravarietyofcellularmetabolicpathwaysresultinginthesynthesisandreleaseofinflammatorymediators.TCCcontainsneoantigensthatareabsentintheindividualnativeC9proteins.NeoantigensarepresentbothinthemembraNEBound(MAC)andthefluidphase(SC5b-9)complex.TCCispresentinnormalhumanplasmaandincreasesuponcomplementactivation.Specifications:CatalognumberHM2264-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).ApplicationFlowcytometry,Frozensections,Immunoassays,Immunofluorescence,Paraffinsections,WesternblotUseForimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.IsotypeMouseIgG1SpeciesHumanReferences1.Breitner-Ruddock,Setal;Heterogeneityinthecomplement-dependentbacteriolysiswithinthespeciesofBorreliaburgdorferi.MedMicrobiolImmunol1997,185:2532.Kraiczy,Petal;BorreliacidalactivityofearlyLymediseaseseraagainstcomplement-resistantBorreliaafzeliiFEM1wild-typeandanOpsC-lackingFEM1variant.JMedMicrobiol2000,49:9173.Meri,Tetal;OnchocercavolvulusMICROFILariaeavoidcomplementattackbydirectbindingoffactorH.JInfectDis2002,185:17864.Würzner,Retal;Blooddendriticcellscarryterminalcomplementcomplexesontheircellsurfaceasdetectedbynewlydevelopedneoepitope-specificmonoclonalantibodies.Immunol1991,74:132StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。