首页 > Hycult Biotech > Hycult Biotech/MPO, Rat, mAb 2D4, immuno assay antibody/HM3030-IA/0.5 mg

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Hycult Biotech/MPO, Rat, mAb 2D4, immuno assay antibody/HM3030-IA/0.5 mg

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HM3030-IA

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Description:MPO,Rat,mAb2D4,immunoassayantibodyThemonoclonalantibody2D4reactswithratmyeloperoxidase(MPO).MPOisaglycoproteinwithanalpha2beta2heteromultimerexpressedinallcellsofthemyeloidlinage.MPOisabundantlypresentinazurophilicgranulesofpolymorphonuclearneutrophils.Itisanimportantenzymeusedduringphagocyticlysisofengulfedforeignparticleswhichtakespartinthedefenseoftheorganismthroughproductionofhypochlorousacid(HOCl),apotentoxidant.MPOisrapidlyreleasedbyactivatedpolymorphonuclearneutrophils.InvolvementofMPOhasbeendescribedinnumerousdiseasessuchasatherosclerosis,lungcancer,Alzheimer"sdiseaseandmultiplesclerosis.AutoimmuneantibodiestoMPOareinvolvedinWegenersdisease.SincethediscoveryofMPOdeficiency,initiallyregardedasrareandrestrictedtopatientssufferingfromsevereinfections,MPOhasattractedmoreclinicalattention.InexperimentalstudiesantibodiestoMPOcanbeusedforvariouspurposesrangingfromflowcytometricanalysistodetectionofpolymorphonuclearneutrophilsintissuesections.Specifications:CatalognumberHM3030-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBSwithaconcentrationofatleast0.5mg/ml(exactconcentrationisindicatedonthelabel).ApplicationFlowcytometry,ImmunoassaysApplicationNotesIA:theantibodycanbeusedasadetectionantibody.FC:Cellsarefixedwith4%paraformaldehydeandpermeABIlizedwith0.1%saponine.UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenMousemyeloperoxidaseIsotypeMouseIgG1SpeciesRatCrossreactivityMouse-YesAliasMyeloperoxidaseGenename:MpoReferences1.Liu,Getal;KinaseAKT1NegativelyControlsNeutrophilRecruitmentandFunctioninMiceJImmunol2013,191:2680StorageandstabilityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseCardiologyandmetabolism,Pulmonology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。