首页 > Hycult Biotech > Hycult Biotech/TCC, Human, mAb aE11, immuno assay antibody/HM2167-IA/0.5 mg

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Hycult Biotech/TCC, Human, mAb aE11, immuno assay antibody/HM2167-IA/0.5 mg

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HM2167-IA

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Description:TCC,Human,mAbaE11,immunoassayantibodyMonoclonalantibodyaE11reactswithaC9neoantigenoftheterminalcomplementcomplex(TCC).ThethreedistinctactivationpathwaysofcomplementconvergewiththeformationofaC5convertase.ThecleavageofC5bythisconvertaseinitiatesthelyticorterminalpathway.Incontrasttotheactivationpathways,whichrequireenzymaticcleavageforactivation,theterminalpathwayreliesonconformationalchangesinducedbybinding.BindingofC6facilitatesbindingofC7whichalterstheconformationofthecomplex.AfterbindingofC8,avariablenumberofC9moleculesassociatewiththeC5b678complex,whichisalsotermed-theterminalcomplementcomplex(TCC).TheformationofTCCcauseslysisofcellsorcantriggeravarietyofcellularmetabolicpathwaysresultinginthesynthesisandreleaseofinflammatorymediators.TheTCCcontainsneoantigensthatareabsentfromtheindividualnativecomponents.-C9neoantigensarepresentbothinthemembrane-bound(MAC)andthefluid-phase(SC5b-9)complex.TCCispresentinnormalhumanplasmaandincreasedinpatientswithcomplementactivation.Specifications:CatalognumberHM2167-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBSwithaconcentrationofatleast0.5mg/ml(exactconcentrationisindicatedonthelabel).ApplicationFlowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunofluorescence,ParaffinsectionsApplicationNotesFS:AntibodyaE11inhibitsplateletactivationbyantiphospholipidantibodyserum.(Ref.5).IF:Cryosectionsof10μmweredried,fixedinacetoneat4°Cfor10min,driedandblockedfor20minwithPBSA.UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.IsotypeMouseIgG2aSpeciesHumanCrossreactivityHorse-Yes,Pig-YesAliasTerminalcomplementcomplex,MACcomplex,complementmembraneattackcomplex,sC5b-9complex.PositiveControlMucosafrompatientswithH.Pylori.References1.Mollnes,Tetal;Quantificationoftheterminalcomplementcomplexinhumanplasmabyanenzyme-linkedimmunosorbentassaybasedonmonoclonalantibodiesagainstaneoantigenofthecomplex.ScandJImmunol1985,22:1972.Mollnes,Tetal;Monoclonalantibodiesrecognizinganeoantigenofpoly(C9)detectthehumanterminalcomplementcomplexintissueandplasma.ScandJImmunol1985,22:1833.Pettersen,Hetal;HumanalveolarmacrophagessynthesizeactivecomplementcomponentsC6,C7,andC8invitro.ScandJImmunol1987,25:5674.Berstad,Aetal;EpitheliumrelateddepositionofactivatedcomplementinHelicobacterpyloriassociatedgastritis.Gut1997,40:1965.Stewart,Metal.Antiphospholipidantibody-dependentC5b-9formation.BJH1997,96:4516.Meuwissen,Metal.ColocalisationofintraplauqCreactiveprotein,complement,oxidisedlowdensitylipoprotein,andmacrophagesinstableandunstableanginaandacutemyocardialinfarction.JClinPath2005,59:126StorageandstABIlityProductshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。