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Hycult Biotech/IFN-gamma, Mouse, mAb F3/HM1002-01/100 µg

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HM1002-01

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Description:IFN-gamma,Mouse,mAbF3MonoclonalantibodyF3bindsandneutralizesbothnaturalandrecombinantmousegammaInterferon.Itsbindingandneutralizingactivityhasbeendemonstratedinvitroandinvivo.F3antibodieshavebeendemonstratedtobeabletoinhibitinflammatoryresponsestobacteriallipopolysaccharides.TheseantibodieswerefurThermoreshowntoinhibitShwartzmanreactionsandtoprotectNZBmiceagainstspontaneousdevelopmentofautoimmunedisease.Theantibodydoesnotreactwithratorhumangammainterferon.Specifications:CatalognumberHM1002-01ProducttypeMonoclonalantibodiesQuantity100µgFormulationLyophilizedproductinPBS,containing100 µg.Reconstitutethevialbyinjectionof0.5mlsteriledistilledorde-ionizedwater(Caution:vialisundervacuum).ApplicationFunctionalstudies,Immunoassays,ImmunoprecipitationUseForneutralisationofBIOLOGicalactivitydilutionshavetobemadeaccordingtotheamountofInterferontobeinactivated.OneneutralizingunitisdefinedastheamountofantibodysufficientforneutralizingoneunitofmousegammaInterferonantiviralactivityascalibratedagainstNIHstandardGg02-901-533.IsotypeRatIgG2aSpeciesMouseReferences1.Armstrong,JAetal;Semi-micro,dye-bindingassayforrabbitinterferon.JApplMicrobiol1971,21:7232.vanTiel,FHetal;DetectionofSemlikiForestvirusincellculturebyuseofanenzymeimmunoassaywithperoxidase-labeledmonoclonalantibodiesspecificforglycoproteinsE1andE2.JClinMicrobiol1984,20:3873.Dijkmans,Retal;HeterogeneityofChinesehamsterovarycell-producedrecombinantmurineinterferon-gamma.JBiolChem1987,262:25284.Heremans,Hetal;Regulationbyinterferonsofthelocalinflammatoryresponsetobacteriallipopolysaccharide.JImmunol1987,138:41755.Billiau,Aetal;anti-interferon-gammaantibodyprotectsmiceagainstthegeneralizedShwartzmanreaction.EurJImmunol1987,17:18516.Jacob,COetal;invivotreatmentof(NZBXNZW)F1lupus-likenephritiswithmonoclonalantibodytogammainterferon.JExpMed1987,166:7987.Wolfs,Tetal;InvivoexpressionofToll-likereceptor2and4byrenalepithelialcells:IFN-gammaandTNF-alphamediatedup-regulationduringinflammation.Jimmunol2002,168:1286StorageandstABIlityLyophilizedproductshouldbestoredat4 °C.Storestocksolutioninaliquotsat-20 °C.Repeatedfreezeandthawcycleswillcauselossofactivity.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseAutoimmunity,Infectiousdiseases

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。