首页 > Hycult Biotech > Hycult Biotech/IL-6, Mouse, mAb MP5-20F3/HM1004-01/100 µg

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Hycult Biotech/IL-6, Mouse, mAb MP5-20F3/HM1004-01/100 µg

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HM1004-01

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Description:IL-6,Mouse,mAbMP5-20F3Theantibodyneutralizesmouseinterleukin6(IL-6).Itdoesnotcross-reactwithLPS(thecomponentofthebacterialcellwallwhichisconsideredresponsIBLeforthetoxicityofgram-negativebacteria)andTNFalphanordoesitbindtoeitherhumanorratIL-6.TheantibodyinhibitsIL-6inducedproliferationoftheB9assay.IL-6isapluripotent20-22kDacytokinewhichplaysaroleinthepathophysiologyofsevereinfectionandregulatestheimmuneresponse,acutephasereactionandhaematopoiesis.IL-6playsacriticalroleinB-celldifferentiationtoplasmacellsandisapotentgrowthfactorforplasmacytomaandmyeloma.ContinuousIL-6geneexpressionmakesanessentialcontributiontoamultisteponcogenesisofplasmacellneoplasia.IL-6isaveryusefulculturesupplementforthegenerationofahighnumberofantibody-producinghybridomas.Specifications:CatalognumberHM1004-01ProducttypeMonoclonalantibodiesQuantity100µgFormulation1ml(100μg/ml)0.2μmfilteredantibodysolutioninPBScontaining0.1%bovineserumalbumin.ApplicationFunctionalstudies,Immunoassays,ImmunoprecipitationApplicationNotesTheantibodycanbeusedforinvitroandinvivoinhibitionofactivityofIL-6.FurThermoretheantibodyisusefulforimmunochemicalinvestigationsofmouseIL-6instructuralstudiesandforquantitative/qualitativeimmunochemicaldetectionmethods.Thisantibodymaybeusedasacoatingantibodyinimmunoassayprocedures.UseForneutralisationofBIOLOGicalactivitydilutionshavetobemadeaccordingtotheamountofIL-6tobeinactivated.IsotypeRatIgG1SpeciesMouseReferences1.Takatsuki,Fetal;HumanrecombinantIL-6/Bcellstimulatoryfactor2augmentsmurineantigen-specificantibodyresponsesinvitroandinvivo.JImmunol1988,141:30722.McKenzie,Detal;AlloantigenpresentationbyBcells.RequirementforIL-1andIL-6.JImmunol1988,141:29073.vanSnick,Jetal;Interleukin-6:anoverview.AnnuRevImmunol1990,8:2534.Heinrich,PCetal;Interleukin-6andtheacutephaseresponse.BiochemJ1990,265:6215.Starnes,HFJretal;Anti-IL-6monoclonalantibodiesprotectagainstlethalEscherichiacoliinfectionandlethaltumornecrosisfactor-alphachallengeinmice.JImmunol1990,145:41856.Hirano,Tetal;Interleukin6(IL-6)anditsreceptor:theirroleinplasmacellneoplasias.IntJCellCloning1991,9:1667.Hooghe-Peters,Eetal;Interleukin-1,interleukin-6:messengersintheneuroendocrineimmunesystem?PatholResPract1991,187:622StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseAutoimmunity,Tumorimmunology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。