首页 > Hycult Biotech > Hycult Biotech/TNF-RI, Mouse, mAb HM104, FITC/HM1009F/100 µg

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Hycult Biotech/TNF-RI, Mouse, mAb HM104, FITC/HM1009F/100 µg

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HM1009F

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Description:TNF-RI,Mouse,mAbHM104,FITCThemonoclonalantibodyHM104recognizestheextracellularpartoftheTumorNecrosisFactorReceptortypeI(TNF-RI)ofthemembrane-boundaswellasthesolublereceptor.TNF-RI(~55-60kDa)ispresentonmostcelltypesandisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha.TNF-alphaactivatesinflammatoryresponses,inducesapoptosis,regulatescellularproliferation,andmayevenpromotecancerprogression.TheeffectsofTNF-alphaaremediatedbyTNF-RIandTNF-RII,whichhavebothdistinctandoverlappingdownstreamsignalingcascades.InductionofcytotoxicityandotherfunctionsaremediatedlargelyviaTNF-RI.TNF-RIisequallywellactivatedbyboththe17kDasolubleand26kDamembrane-boundform,whereasTNF-RIIisefficientlyactivatedonlybythemembraneboundformofTNF-alpha.TNF-RIsignalingisinitiatedwhentrimericTNF-alphabindsTNF-RIreceptors.SubsequentTNF-RItrimerizationpromotestherecruitmentofaproximalsignalingcomplexcomposedofTNFReceptorAssociatedproteinwithaDeathDomain(TRADD),ReceptorInteractingProtein(RIP),cellularInhibitorofApoptosisProtein1(cIAP1),TNFReceptorAssociatedFactor2(TRAF2),andlikelyTRAF5.StudieswithTNF-RI-deficientmiceindicatethatTNF-RImediatesmostoftheproliferation,pro-inflammatory,andapoptosis-activatingpathways.Specifications:CatalognumberHM1009FProducttypeMonoclonalantibodiesQuantity100µgFormulation1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide.ConjugateFITCApplicationFlowcytometry,Frozensections,ImmunoassaysApplicationNotesThemonoclonalantibodyHM104canbeusedforimmunoassay,andflowcytometry.FurThermore,themonoclonalantibodyHM104isusefulforimmunoprecipitationandimmunohistologyonfrozensections.BeawarethatthereactivityoftheantibodywithsolubleTNF-ReceptorisinhibitedbyhighconcentrationsofbothmouseandhumanTNF-alpha.UseForimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.IsotypeRatIgG2aSpeciesMouseAliasCD120a,Tumornecrosisfactorreceptorsuperfamilymember1A,p55/p60,TNF-RIReferences1.Bigini,Petal;ImmunohistochemicallocalizationofTNFαanditsreceptorsintherodentcentralnervoussystem.MethodsMolMed2004,98:732.Mennini,Tetal;GlialactivationandTNFR-Iupregulationprecedesmotordysfunctioninthespinalcordofmndmice.Cytokine2004,25:1273.Ghezzi,Petal;Tumornecrosisfactorasapharmacologicaltarget.MethodsMolMed2004,98:1StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.DiseaseAutoimmunity,Gastroenterology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。