首页 > Hycult Biotech > Hycult Biotech/TNF-RII, Mouse, mAb HM102/HM1011/100 µg

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

Hycult Biotech/TNF-RII, Mouse, mAb HM102/HM1011/100 µg

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

HM1011

品牌：

Hycult Biotech

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

Description:TNF-RII,Mouse,mAbHM102ThemonoclonalantibodyHM102recognizestheextracellularpartofmembrane-boundTNF-RIIaswellasthesolubleformofTNF-RIIwhichisgeneratedbyproteolyticcleavageoftheextracellulardomain.ThesolubleformcanstillbindTNF-alphawithhighaffinityandfunctionsasaTNF-alphaantagoNIST.TNF-alphaisanimportantsignallingproteinintheimmunesystemwhichcanactivateinflammatoryresponses,induceapoptosis,regulatecellularproliferation,andmayevenpromotecancerprogression.TNF-alphacanbindtotwostructurallydistinctmembranereceptors,TNF-RIandTNFRII,whichhavebothdistinctandoverlappingdownstreamsignalingcascades.TNFRIisbelievedtobeexpressedonnearlyallcelltypes,whereasTNFRIIexhibitsmorerestrictedexpression,beingfoundoncertainsubpopulationsofimmunecellsandseveralothercelltypes.AdominantroleofTNFRIIhasbeenshowninthymocyteactivationbyTNF-alpha,whereasinductionofcytotoxicityandotherfunctionsaremediatedlargelybyTNF-RI.TNF-RIisequallywellactivatedbyboththe17kDasolubleand26kDamembrane-boundform,whereasTNF-RIIisactivatedonlybythemembraneboundformofTNF-alpha.Theantibodyisaagonisticreceptormodulatingantibody.ItenhancesinvitroTNFalpharesponsesbyincreasingtheaffinityofthesolubleformofTNF-alphaforTNF-RII.Specifications:CatalognumberHM1011ProducttypeMonoclonalantibodiesQuantity100µgFormulation1ml(100μg/ml)0.2μmproteinGpurifiedantibodysolutioninPBS,containing0.1%bovineserumalbumin.ApplicationFlowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunoprecipitation,WesternblotApplicationNotesFS:Inmostcases2μg/mlactsagonisticallyFC:100.000microgliacellswereincubatedwith10μg/mlPBS/1%serumfor30minoniceW:AreducedsampletreatmentandSDS-Pagewasused.Thebandsize(s)is75kDa(Ref.4).UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting.IsotypeRatIgG2aSpeciesMouseAliasTumornecrosisfactorreceptorsuperfamilymember1B,CD120b,TNF-R2,p75,p80TNF-alphareceptorGenename:Tnfrsf1bPositiveControlRAW264.7cellsReferences1.Tacchini-Cottier,Fetal;RoleofTNFR1andTNFR2inTNF-inducedplateletconsumptioninmice.JImmunol1998,160:61822.Brekke,Oetal.Specificityofendogenousfattyacidreleaseduringtumornecrosisfactor-inducedapoptosisinWEHI164fibrosarcomacells.JofLipidres.1999,40:22233.Marchetti,Letal;TumorNecrosisFactor(TNF)-mediatedneuroprotectionagainstglutamate-inducedexcitotoxicityisenhancedbyN-methyl-D-aspartatereceptoractivation.JBiolChem2004,279:328694.Taoufik,Eetal;FLIPLprotectsneuronsagainstinvivoischemiaandinvitroglucosedeprivation-inducedcelldeath.JNeurosci2007,27:66335.Veroni,Cetal;ActivationofTNFreceptor2inmicrogliapromotesinductionofanti-inflammatorypathways.MolCellNeurosci2010,45:2346.Chee,Jetal.TNFreceptor1deficiencyincreasesregulatoryTcellfunctioninnonobesediabeticmice.Jimmunol2011,187:1702-1712StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.DiseaseAutoimmunity,Gastroenterology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。