首页 > ACROBiosystems > ACROBiosystems/Human Osteoactivin / GPNMB Protein, His Tag/100ug/GPB

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ACROBiosystems/Human Osteoactivin / GPNMB Protein, His Tag/100ug/GPB

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SynonymGPNMB,HGFIN,NMB,OsteoactivinSourceHuman Osteoactivin, His Tag (GPB-H5229) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Pro 486 (Accession # AAH32783).Predicted N-terminus: Ala 22Request for sequenceMolecular CharacterizationThis protein carries a polyhistidine tag at the C-terminus.The protein has a calculated MW of 53.4 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.EndotoxinLess than 1.0 EU per μg by the LAL method.Purity>95% as determined by SDS-PAGE.FormulationLyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.Contact us for customized product form or formulation.ReconstitutionPlease see Certificate of Analysis for specific instructions.For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.StorageFor long term storage, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. SDS-PAGEHuman Osteoactivin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Citations Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteasesAuthors: Arosarena OA, et al.Journal: J Cell Physiol 2017Application: Cell cultureRequest for Full-text BackgroundTransmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. References (1)Weterman MA., et al., 1995, International Journal of Cancer 60 (1): 73–81. (2)Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334–51. (3)Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26–37.Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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