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Bpsbioscience/2-Methoxyestradiol (2-MeOE2)/27762-1/50 mg

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27762-1

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4000-520-616

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MW:302.4DaCASRegistry#:362-07-2Formula:C19H26O3Background:2-MethoxyestrADIoliscurrentlyinclinicaltrialsasatherapeuticagainstbreastandovariancancer.Preclinicalmodelsalsosuggestthat2ME2couldalsobeeffectiveagainstinflammatorydiseasessuchasrheumatoidarthritis.Severalstudieshavebeenconductedshowing2ME2isamicrotubule-inhibitorandeffectiveagainstprostatecancerinrodentsDescription:2-Methoxyestradiol(2-MeOE2),anendogenousmetaboliteof17β-estradiol(E2),isaninhibitorofmicrotubuleassemblythatinhibitsthepolymerizationoftubulinandinterfereswithmitoticspindledynamicsleadingtotheblockageofmitosisofhumancancercellswhichlackestrogenreceptorsinmetaphase.2-MeOE2isalsoaninhibitoroftumorgrowthandangiogenesis.Studyresultshaveshownthat2-MeOE2inducesmammaliancelltransformationandgenotoxicityinSyrianhamsterembryo(SHE)fibroblaststhroughconcentration-dependentinhibitionofcellgrowth.Moreover,2-MeOE2hasdemonstratedanti-proliferativeactivityagainstestrogen-responsivebreastcancercelllineMCF-7andsubsequentinhibitionofthegrowthoftumorssubcutaneouslyinoculatedinmice.Synonym(s):2-Methoxyestradiol;2-MeOE2;2-methoxyEstradiolPurity:98%puritybyHPLCSolubility:SolubleinDMSO~20mg/mlStorage/StABIlity:Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.Reference(s):1.Tsutsui,T.,etal.Carcinogensis2000;21(4):735-740.2.Attalla,H.,etal.Biochem.Biophys.Res.Commun.1996;228:467-473.ScientificCategory:ApoptosisInducerProductType:Activator/InducerDatashownislot-specific.Contactusforspecificinformationonotherlots.

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