首页 > BPS Bioscience > Bpsbioscience/PDE10A-HEK293 Recombinant Cell line/60410/2 vials

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Bpsbioscience/PDE10A-HEK293 Recombinant Cell line/60410/2 vials

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60410

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4000-520-616

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Species:HumanHostSpecies:HEK293(human)Genbank#:NM_006661Background:Phosphodiesterases(PDEs)regulatetheintracellularlevelsofcAMPandcGMPbyhydrolyzingcAMPandcGMPtotheirinactive5"monophosphates.Thesecyclicnucleotidesplayanimportantroleassecondmessengersindiversephysiologicalfunctions.PDE10Aplaysakeyroleinsignaltransductionbyregulatingtheintracellularconcentrationofcyclicnucleotides.PDE10AhydrolyzesbothcAMPandcGMPtonucleoside5?-monophosphate,butexhibitshigheraffinityforcAMP,anditutilizescAMPmoreefficientlyasasubstrate(FujishigeK.etal.,1999).Description:RecombinantHEK293celllineexpressinghumanPDE10A2(phosphodiesterase10A,accessionnumberNM_006661).N-terminalHis-taggedhumanPDE10A2hasbeenstablyexpressedinahumanembryonickidney(HEK293)cellline.PDE10A2expressionwasconfirmedbyWesternblotting.ThefunctionofPDE10A2wasconfirmedbycAMPdetectionassay.ForskoliniscommonlyusedtoraiselevelsofintracellularcyclicAMP(cAMP).WhenHEK293cellsareactivatedbyforskolin,cAMPlevelsareupregulatedinparentalcells,whereascellsoverexpressingPDE10AshowreductionincAMPaccumulation.InhibitionofPDE10AactivityrestorescAMPlevels.UniProtQ9Y233Synonym(s):PDE10A,phosphodiesterase10ASuppliedAs:Eachvialcontains~1X106cellsin1mlof10%DMSO.MycoplasmaTesting:ThecelllinehasbeenscreenedusingthePCR-basedVenorGeMMycoplasmaDetectionkit(SigmaAldrich)toconfirmtheabsenceofMycoplasmaspecies.Format:aqueoussolutioncontainingDMSOInstructionsforuse:Seedatasheetfordetailedculturingandassayprotocol.Storage/StABIlity:Storeinliquidnitrogenimmediatelyuponreceipt.Application(s):UsefultomonitorcAMPandPDE10AsignalingpathwayactivityandtoscreenactivatorsorinhibitorsofPDE10A.Notes:Contactusforpricing.LicenseDisclosure:Purchaseofthiscelllinegrantsyouwitha10-yearlicensetousethiscelllineinyourimmediatelaboratory,forresearchuseonly.Thislicensedoesnotpermityoutoshare,distribute,sell,sublicense,orotherwisemakethecelllineavailableforusetootherlaboratories,departments,researchinstitutions,hospitals,universities,orbiotechcompanies.Thelicensedoesnotpermituseofthiscelllineinhumansorfortherapeuticordruguse.Thelicensedoesnotpermitmodificationofthecelllineinanyway.InappropriateuseordistributionofthiscelllinewillresultinrevocationofthelicenseandresultinanimmediateceaseofsalesanddistributionofBPSproductstoyourlaboratory.BPSdoesnotwarrantthesuitabilityofthecelllineforanyparticularuse,anddoesnotacceptanyliabilityinconnectionwiththehandlingoruseofthecellline.Modificationsofthiscellline,transfertoanotherfacility,orcommercialuseofthecellsmayrequireaseparatelicenseandadditionalfees;contactsales@bpSBIoscience.comfordetails.PublicationsusingthiscelllineshouldreferenceBPSBioscience,Inc.,SanDiego.Warning(s):Avoidfreeze/thawcyclesScientificCategory:PDEProductType:CellLineDatashownislot-specific.Contactusforspecificinformationonotherlots.

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