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Bpsbioscience/Apoptosis Activator 2/27733-3/100 mg

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27733-3

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MW:306.1DaCASRegistry#:79183-19-0Formula:C15H9Cl2NO2Target:CaspaseBackground:ApoptosisActivator2isacell-permeableindoledionecompoundthatactivatescaspasesinacytochromec-dependentmannerandinducesapoptosisintumorcellsbypromotingtheoligomerizationofApaf-1intothematureapoptosome.Itscytotoxicityisselectivetowardstumorcells(IC5040µM).Throughtheinductionofapoptosis,ApoptosisActivator2notablyinducescaspase-3activation,PARPcleavageandDNAfragmentation.Moreover,thisinductionofapoptosisonlyoccursintumorcelllines(suchasbreast,lung,colon,andepidermalcancercelllines).Description:ApoptosisActivator2isasmall,cellpermeableactivatorofcaspase-3.ApoptosisActivator2inducesapoptosisspecificallyintumorcelllines,butnotnormalcelllines,withIC50valueofabout4µM.Synonym(s):ApoptosisActivatorII;AG-H-17727;ZINC02276110;1-[(3,4-dichlorophenyl)methyl]indole-2,3-dioneBIOLOGicalActivity:Inducesapoptosisoftumorcelllines,includingBT-549:IC50=20µM;NCI-H23:IC50=35µM;Jurkat:IC50=4µM;Molt-4:IC50=6µM;andCCRF-CEM:IC50=9µM.Solubility:SolubleinDMSO(5mg/ml),methanol(5mg/ml),andethanol.Storage/StABIlity:Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.Reference(s):1.NguyenJT,WellsJA.ProcNatlAcadSciUSA.2003Jun24;100(13):7533-8.2.NguyenTV,etal.JNeuroendocrinol.2010Sep;22(9):1013-22.ScientificCategory:ApoptosisActivatorProductType:Activator/InducerDatashownislot-specific.Contactusforspecificinformationonotherlots.

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