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Bpsbioscience/Boc-D-FMK/27611-1/5 mg

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27611-1

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MW:263.3DaCASRegistry#:187389-53-3,634911-80-1Formula:C11H18FNO5Target:pan-caspaseBackground:Boc-D-FMKisacell-permeablebroad-spectrumcaspaseinhibitorthatfullyinhibitsthepro-apoptoticeffectoftumornecrosisfactor-α(TNFα)withIC50valueof39µM.Boc-D-FMKhasbeenfoundtoreducetheactivationofnuclearfactorkappalightchainenhancerofactivatedBcells(NF-kB),suppressthephosphorylationofsubunitnuclearfactorkappalightpolypeptidegeneenhancerinBcellsinhibitorα(IkBα)andinhibitsTNF-inducedexpressionofintercellularadhesionmolecule1(ICAM-1)andvascularcelladhesionmolecule1(VCAM-1).Moreover,Boc-D-FMKhasalsoeffectivelyattenuatedthehepatocyteapoptosisinbileduct-ligatedratspotentiallyimprovingthesurvivalrates.Description:AsyntheticpeptidethatirreversIBLyinhibitsactivityofcaspasefamilyproteasesandblocksapoptosis.TheinhibitorisdesignedasamethylestertofacilitatecellpermeABIlity.Canbeusedforbothinvitroandinvivostudies--seenoteforusingthisproductinvitro.Synonym(s):CaspaseInhibitorIII;Boc-Asp(OMe)-FMK;Boc-D(OMe)-FMK;Boc-Asp-Fluoromethylketone;methyl5-fluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopentanoatePurity:≥98%byHPLCSolubility:SolubleinDMSOStorage/Stability:Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.Reference(s):1.CowburnAS,etal.Blood.2005Apr1;105(7):2970-2.2.WuX,etal.AmJPhysiolRenalPhysiol.2009Aug;297(2):F316-26.3.Sheen-ChenSM,etal.JGastroenterolHepatol.2008Aug;23(8Pt1):1276-9.Notes:Theinhibitorisdesignedasamethylestertofacilitatecellpermeability.Iftheintendeduseisonpurifiedorrecombinantenzymes,esteraseshouldbeaddedtogeneratefreecarboxylgroups.AminoAcidSequence:Boc-Asp(OMe)-CH?FScientificCategory:ApoptosisInhibitorProductType:InhibitorDatashownislot-specific.Contactusforspecificinformationonotherlots.

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