首页 > BPS Bioscience > Bpsbioscience/Anti–ER alpha monoclonal antibody/25221/100 µl

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Bpsbioscience/Anti–ER alpha monoclonal antibody/25221/100 µl

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25221

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HostSpecies:MouseClonality:monoclonalBackground:Theestrogenreceptoralpha(ERalpha,UniProt/Swiss–ProtentryP03372)belongstothefamilyofnuclearhormonereceptors,whichareligand–activatedtranscriptionfactors.Theyareimportantfortheregulationofgeneexpression,cellularproliferationanddifferentiation,sexualdevelopmentandreproductivefunction.Estrogenreceptorsarealsoinvolvedinpathologicalprocessessuchasbreastcancer,andosteoporosis.ERalphacanregulatetranscriptionbydirectbindingtoestrogenresponseelements(EREs)intheDNAorbyinteractionwithothertranscriptionfactors.ItmayalsoformaheterodimerwithERbeta.Description:MonoclonalantibodyraisedinmouseagainsthumanERalpha(estrogenreceptoralpha),usingasyntheticpeptideSynonym(s):ESR,ESR1,ESRA,NR3A14AssayConditions:ChIP-seqresultsobtainedwiththemonoclonalantibodydirectedagainstERalphaChIPwasperformedwiththemonoclonalantibodyagainstERalpha(Cat.#25221)onshearedchromatinfromMCF7cellstreatedfor1hourwithestrADIol.TheimmunoprecipitatedDNAwasanalyzedwithanIlluminaGenomeAnalyzer.Librarypreparation,clustergenerationandsequencingwereperformedaccordingtothemanufacturer"sinstructions.The36bptagswerealignedtothehumangenomeusingtheELANDalgorithm.Figure1showstheobtainedpeaksneartheTFF1geneonchromosome21(figure1A),theGREB1andHAAOgenesonchromosome2(figure1BandC),andtheZNF185geneontheX-chromosome(figure1D).Concentration:100µlFormulation:Ascitesfluidfrommousecontaining0.05%azideSpeciesReactivity:HumanCrossReactivity:Doesnotreactwithchicken;otherspeciesnottestedPurification:AscitesfluidImmunogen:syntheticpeptideFormat:aqueoussolutionStorage/StABIlity:Storeat–80°Cforupto2years.Centrifugeafterfirstthawtomaximizeproductrecovery.Aliquottoavoidrepeatedfreeze/thawcycles.Aliquotsmaybestoredat–20°Cforatleastonemonth.Application(s):ChIP/ChIP–seq(2.5µl)ELISA(1:500–1:5000)WB(1:500–1:5000)GelSupershift(1:10–1:20)Immunochemistry(1:500–1:5000)IP(1:200–1:5000)Notes:TheoptimalantibodyamountperIPshouldbedeterminedbytheend–user.Werecommendtesting1–5µgperIPWarning(s):Avoidfreeze/thawcyclesScientificCategory:AntibodiesProductType:AntibodyDatashownislot-specific.Contactusforspecificinformationonotherlots.

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