首页 > BPS Bioscience > Bpsbioscience/Myc Reporter Kit (Myc Signaling Pathway)/60519/500 reactions

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Bpsbioscience/Myc Reporter Kit (Myc Signaling Pathway)/60519/500 reactions

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60519

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4000-520-616

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Background:TheMycsignalingpathwayplaysanimportantroleincellproliferation,differentiation,transformationandapoptosis.Thec-MycproteinisatranscriptionfactorthatheterodimerizeswithMaxtoregulateMycsignalingpathwayresponsivegenes.Mycmutationshavebeenlinkedtothedevelopmentofanumberofhumancancers,includingBurkitt’slymphoma,cervical,ovarian,breast,lungandpancreaticcarcinoma,makingMycapromisingtherapeutictargetforcancertreatment.Description:TheMycPathwayReporterkitisdesignedformonitoringtheactivityoftheMycsignalingpathwayinculturedcells.Thekitcontainsatransfection-readyexpressionvectorforc-MycandMycluciferasereportervector.Insidethecells,c-MycwillbindtoMax,translocatetothenucleus,andinduceexpressionoftheMycluciferasereportervector.ThisreportercontainsthefireflyluciferasegeneunderthecontrolofmultimerizedMycresponsiveelementslocatedupstreamofaminimalpromoter.TheMycreporterispremixedwithconstitutively-expressingRenilla(seapansy)luciferasevector,whichservesasaninternalpositivecontrolfortransfectionefficiency.Thekitalsoincludesanon-inducIBLefireflyluciferasevectorpremixedwithconstitutivelyexpressingRenillaluciferasevectorasanegativecontrol.Thenon-inducibleluciferasevectorcontainsafireflyluciferasegeneunderthecontrolofaminimalpromoter,butwithoutanyadditionalresponseelements.Thenegativecontroliscriticalfordeterminingpathway-specificeffectsandbackgroundluciferaseactivity.Format:COMPONENTSInstructionsforuse:Seedatasheetfordetailedtransfectionandassayprotocols.Storage/StABIlity:Stableatleast12monthsfromdateofreceipt,whenstoredasdirected(-20°C).Application(s):•MonitorMycsignalingpathwayactivity.•ScreenactivatorsorinhibitorsoftheMycsignalingpathway.•StudyeffectsofRNAiorgeneoverexpressionontheactivityoftheMycpathway.Reference(s):1.PelengarisS,etal.(2002)c-MYC:morethanjustamatteroflifeanddeath.Nat.Rev.Cancer.2(10):764-76.Notes:Thevectorsaresuitablefortransienttransfection.TheyareNOTsuitablefortransformationandamplificationinbacteria.Warning(s):Avoidfreeze/thawcyclesScientificCategory:CellSignallingPathwayProductType:ReporterAssayKitDatashownislot-specific.Contactusforspecificinformationonotherlots.

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