DescriptionPublicationsSpecification SheetRatings (1)body { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductADCY6 AntibodyDescriptionAffinity Purified Adenylate cyclase type 6 Antibody Verified ApplicationsCM, ELISA, ICC, IF, IHC, IP, WBHostRabbitSpecies Cross ReactivityHuman, Rat, MouseImmunogenSynthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.Sequence:DERKTAWGERNGQKRAccession #GenBank: AAD29856.1Physical PropertiesQuantity100 µgVolume200 µlConcentration0.59 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolConfocal Microscopy1:100-1:200Dot Blot1:10,000ELISA1:10,000Immunocytochemistry1:100-1:200Immunofluorescence1:100-1:200Immunohistochemistry1:100-1:200Western Blot1:500ProteinUniprot #Q03343OverviewMembrane bound calcium-inhibitable adenylyl cyclase.Molecular FunctionAdenylate cyclase activity; cAMP biosynthesis; ATP-binding; Magnesium; Metal binding; Nucleotide-bindingSubcellular LocationMembrane; Multi-pass membrane protein; Cell projection; ciliumStructurePart of a complex containing AKAP5, ADCY5, PDE4C, PKD2. Interacts with RAF1.Alternative NomenclatureAC6ACVIADCYBAdenylate cyclase 6ATP pyrophosphate-lyase 6Ca(2+) inhibitable adenylyl cyclaseEC 4.6.1.1KIAA0422Protein information supplied by UniProtbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }Fabgennix ADCY6 Antibody has been used in 7 PublicationsKwon, Ronald Y. et al. “Primary Cilium-Dependent Mechanosensing Is Mediated by Adenylyl Cyclase 6 and Cyclic AMP in Bone Cells.”The FASEB Journal24.8 (2010): 2859–2868.PMC2909282 Confocal Microscopy, Immunofluorescence, Western Blot; HumanDesch, Michael, et al. "PPARγ-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of camp on renin gene expression." Molecular Endocrinology 24.11 (2010): 2139-2151.PMID20861226Western Blot; MouseBazhin, Alexandr V., et al. "Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells." Molecular immunology 47.4 (2010): 678-684. PMID19939455Western Blot; MouseMasyuk, Anatoliy I. et al. “Cholangiocyte Primary Cilia Are Chemosensory Organelles That Detect Biliary Nucleotides via P2Y12Purinergic Receptors.”American Journal of Physiology - Gastrointestinal and Liver Physiology295.4 (2008): G725–G734. PMC2575915 Confocal Microscopy, Immunofluorescence; RatMasyuk, Anatoliy I. et al. “Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them into Intracellular Ca2+and cAMP Signaling” Gastroenterology131.3 (2006): 911–920. PMC1866168 Confocal Microscopy, Immunofluorescence; RatGrünberger, Christian, et al. "The Calcium Paradoxon of Renin Release Calcium Suppresses Renin Exocytosis by Inhibition of Calcium-Dependent Adenylate Cyclases AC5 and AC6." Circulation research 99.11 (2006): 1197-1206.PMID17068292 Western Blot; RatKolachala, Vasantha, et al. "Interferon-γ down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase." Journal of Biological Chemistry 280.6 (2005): 4048-4057. PMID15550390Western Blot; HumanPublishing research using PAC-601AP? Please let us know, we can cite the reference in this datasheet.To view the Specification Sheet for ADCY6 Antibody, please click the link below:ADCY6 Antibody | FabGennix Customer ratings for ADCY6 Antibody Number of ratings: 1Average rating: 3Averagefrom Verified Customer on 1/5/2021Western blot using whole rat heart tissue lysate. Loaded 30 µg into 8% reduced denaturing gel. Blocked with 5% BSA for 1 hour at room temperature. 1/500 primary antibody dilution for 20 hours at 4°C in 5% BSA in TBST buffer.

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