首页 > FabGennix > FabGennix/Ephrin Receptor A3 Antibody/EPHAR3-301AP

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FabGennix/Ephrin Receptor A3 Antibody/EPHAR3-301AP

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EPHAR3-301AP

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Descriptionbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductEphrin Receptor A3 AntibodyDescriptionAffinity Purified Ephrin Type-A Receptor 3 Antibody Verified ApplicationsELISA, IP, WBHostRabbitSpecies Cross ReactivityHuman, Mouse, RatImmunogenSynthetic peptide taken within amino acid region 900-980 on human EPHA3 proteinPhysical PropertiesQuantity100 µgVolume200 µlConcentration0.55-0.75 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolDB1:10,000ELISA1:10,000Immunoprecipitation1:200Western Blot1:500ProteinUniprot #P29320OverviewReceptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.Molecular FunctionATP binding; Nucleotide bindingSubcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: SecretedExpressionWidely expressed. Highest level in placenta.StructureHeterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding.Alternative NomenclatureAW492086 antibodyCek4 antibodyEC 2.7.10.1 antibodyEK4 antibodyEnd3 antibodyEph receptor A3 antibodyEPH-like kinase 4 antibodyEPH-like tyrosine kinase 1 antibodyEphA3 antibodyEphrin type-A receptor 3 antibodyETK 1 antibodyETK antibodyHEK 4 antibodyHEK antibodyHuman embryo kinase 1 antibodyMek4 antibodyMGC109882 antibodyReceptor tyrosine kinase HEK antibodyTyro 4 antibodyTyrosine-protein kinase TYRO4 antibodyProtein information supplied by UniProt

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